DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t1 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	136/509 - (26%)
Similarity:	251/509 - (49%)	Gaps:	54/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLVVTIVWLWQILHFWH---WRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYESKEAAGRA 90
            :|:.|.:.|:.|...:.   :::||:|.....|..|.::|...|...|.|...:.|      |:.
  Rat    13 VLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTIFNYGDGMWKFDDDCYKKY------GKI 71

  Fly    91 FVGIDVLHNHALLLRDPALIKRIMVED-FAQFSSRFETTDPTC-DTMG--SQNLFFSKYETWRET 151
            : |........|.:.||.:||.::|:: ::.|::|      .| ..||  .:.:..|:.|.|:..
  Rat    72 W-GFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNR------RCFGPMGFMKKAITMSEDEEWKRL 129

  Fly   152 HKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFGIE 216
            ..|.:|.|.:||::.|:.|:...|..|.:::.::.:..:  .:.:|.:...::.|:|...:||:.
  Rat   130 RTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGE--PINMKDIFGAYSMDVITGTSFGVN 192

  Fly   217 AHSLQNPEAEF-----RRMCIEVNDPRPKRLLHLFTMFFFPRLS---HRVGTHLYSEEYERFMRK 273
            ..||.||:..|     :.:..::.||      .|.::..||.|:   ..:...::..:...|.:|
  Rat   193 VDSLNNPQDPFVQKAKKILKFQIFDP------FLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKK 251

  Fly   274 SMDYVLSQRAESGE-NRHDLIDIFLQLKRTEPAESIIHRPDF-FAAQAAFLLLAGFDTSSSTITF 336
            .:..:...|.:|.: :|.|.:.:.:..:.::..||.....|. .||||...:..|:|.:|::|:|
  Rat   252 FVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSISF 316

  Fly   337 ALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNS 401
            .:||||....:|.:|:.|:..||.:.  ..::.|.:..:.||..||:|.|||||....|||.  |
  Rat   317 IMYELATRPNVQKKLQNEIDRALPNK--APVTYDALMEMEYLDMVVNESLRLYPIATRLDRV--S 377

  Fly   402 RTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFG 466
            :...::   ||   ..:..||.|.|.:..:||:.:||..||.|:|||||.|.:....|..|||||
  Rat   378 KKDVEI---NG---VFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDPYVYLPFG 436

  Fly   467 AGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMR------FDPKAFVL 514
            .|||.|||.....:.:|:.::.:|.:|.::.||:|...::      |.|:..::
  Rat   437 NGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQPEGPII 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	121/444 (27%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	123/455 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820