DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	529	Identity:	132/529 - (24%)
Similarity:	219/529 - (41%)	Gaps:	67/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GCLLVVTIVWLWQIL-----HFW--HWRRLGVPFVPAAPFVGNVWNLLRGACC---FGDQFRELY 81
            |.|.|:.::.|..:|     |:.  .|....:...|:.|   :.|  |.|.|.   ..::.|.:.
Mouse    17 GFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPP---SHW--LFGHCLQFKVDEELRWIL 76

  Fly    82 ESKEAAGRAFVGIDVLH----NHALL-LRDPALIKRIMVEDFAQFS-SRFETTDPTCDTMGSQNL 140
            ...|....||     ||    :|..: :.||..:|.|:.....:.| .||.|     ..:| ..|
Mouse    77 RYLEKFPGAF-----LHWIWGSHVFIKVCDPDYMKVILGRADPKASLYRFLT-----PWLG-HGL 130

  Fly   141 FFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTT 205
            ||...:.|.:..::..|.|....::...|::.:..|.:.|..|| ::.:| :.||:....:|...
Mouse   131 FFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQ-IACQD-ITLEIFHPISLMML 193

  Fly   206 DIIASLAFGIEAH-SLQNPEAEFRRMCIEVNDPRPKRLLHLF--TMFFFPRLSHRVGT------- 260
            |.|...||..:.. .|......:.:...::|:....|:.::|  ....:...||...|
Mouse   194 DTIMKYAFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIA 258

  Fly   261 HLYSEEYERFMRKSMDYVLSQRAESGENRHDLIDIFLQLKRTEPAESIIHRPDFFAAQAAFLLLA 325
            |.:::...:..:..:....|.:...|:...|.:||.| |.|.:...|:..:.  ..|:...|:..
Mouse   259 HEHTDRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILL-LSRMDDGSSLSDKA--LRAEVDSLMFG 320

  Fly   326 GFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYP 390
            |.||.:|.|::..|.||.:...|.|.|.|:::.|  .....::.|.:..:.|....:.|.|||||
Mouse   321 GHDTPASGISWVFYALATHPDHQQRCREEVQSLL--GDGSPITWDHLHQMPYTTMCIKEALRLYP 383

  Fly   391 PTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQ 455
            |...:.|..::...:.    :|.|   |..|..|.:....:|.:.:.|||||||||.||:....|
Mouse   384 PIPSVGRKLSTPVTFP----DGRS---LPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNSVQ 441

  Fly   456 QHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDP---KAFVLTAH 517
            ..|  .:|||..|.|.|||..|....:||.:...|..|.:      ||:....|   :..||.:.
Mouse   442 HSH--AFLPFSGGSRNCIGKHLAMNVLKVAVALTLLRFEL------LPDPSRVPIPTQQLVLKSK 498

  Fly   518 NGTYLRFVK 526
            ||.||...|
Mouse   499 NGIYLHLRK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	110/442 (25%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	122/488 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010