DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	133/525 - (25%)
Similarity:	243/525 - (46%)	Gaps:	76/525 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLPVVLRGGCLLVVTI---VWLWQILHFWHWRRLGVPFVPAAPFVGNV-------WNLLRGACC- 72
            |:|.:.....:|:.||   ::|:......::::||:......|||||:       |...|.  |
  Rat     3 LIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPLPFVGNILAYRHGFWEFDRH--CH 65

  Fly    73 --FGDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVED-FAQFSSRFETTDPTCDT 134
              :||.: ..||.::.              .|.:.||.:||.::|:: ::.|::|        .:
  Rat    66 KKYGDIW-GFYEGRQP--------------ILAITDPDIIKTVLVKECYSTFTNR--------RS 107

  Fly   135 MGSQNLF-----FSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMEL 194
            .|...:.     .|:.|.|:....:.:|.|.:||::.|:.::......|.:::  |........:
  Rat   108 FGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV--KHEAEKGNPI 170

  Fly   195 EVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLL-------HLFTMFFFP 252
            .:|.:...::.|:|...:||:...||.||:..|.:        :.|:||       ...::..||
  Rat   171 TMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQ--------KVKKLLKFNFLDPFFLSVILFP 227

  Fly   253 RLS---HRVGTHLYSEEYERFMRKSMDYVLSQR-AESGENRHDLIDIFLQLKRTEPAESIIHRPD 313
            .|:   ......::.::..:|.|.|::.:...| .|..:.|.|.:.:.:..:.:...||.....|
  Rat   228 FLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMINSQSSGDKESHQGLTD 292

  Fly   314 F-FAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVY 377
            . ..||:.|.:.||::|:||.::||||.||.:..:|.:|:.|:.|||.:.  ..::.|.:..:.|
  Rat   293 VEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAALPNK--APVTYDVLVEMEY 355

  Fly   378 LRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPE 442
            |..|::|.|||:|....|:|.|......     ||   ..:..||.|.:....:|:|.:.||.||
  Rat   356 LDMVLNETLRLFPVGGRLERVCKKDVEI-----NG---VFIPKGTVVMVPTFALHKDPKCWPEPE 412

  Fly   443 VFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRF 507
            .|.||||..:.:...:|..|||||.|||.|||.....:.:|:.|:.:|.:|...:|:.|...::.
  Rat   413 EFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKL 477

  Fly   508 DPKAF 512
            ..|.|
  Rat   478 RKKGF 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	113/440 (26%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	125/489 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820