DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	515	Identity:	135/515 - (26%)
Similarity:	246/515 - (47%)	Gaps:	52/515 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQ 76
            |||.:.:||.|.|        .:::|:.......::|||:|.....|.:|||.:..:|...|.
Human     7 LAVETWLLLAVSL--------VLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFD-- 61

  Fly    77 FRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVED-FAQFSSRFETTDPTCDTMGSQNL 140
             .|.|:........:.|    ....|.:.||.:|:.::|:: ::.|::| .:..|......:.:|
Human    62 -TECYKKYGKMWGTYEG----QLPVLAITDPDVIRTVLVKECYSVFTNR-RSLGPVGFMKSAISL 120

  Fly   141 FFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTT 205
              ::.|.|:....:.:|.|.:||::.|:.::...|..|..::.::  ......:.:|.:...::.
Human   121 --AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE--AEKGKPVTLKDIFGAYSM 181

  Fly   206 DIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLH------LF-TMFFFPRLS---HRVGT 260
            |:|...:||:...||.||:..|    :|    ..|:.|.      || ::..||.|:   ..:..
Human   182 DVITGTSFGVNIDSLNNPQDPF----VE----STKKFLKFGFLDPLFLSIILFPFLTPVFEALNV 238

  Fly   261 HLYSEEYERFMRKSMDYVLSQRA-ESGENRHDLIDIFLQLKRTEPAESIIHRPDF-FAAQAAFLL 323
            .|:.::...|:.||::.:...|. :..::|.|.:.:.:..:.::..||.....|. .|||:...:
Human   239 SLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFI 303

  Fly   324 LAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRL 388
            .||::|:||.::|.|||||.:..:|.:|:.|:.|.|.:....  :.|.|..:.||..||:|.|||
Human   304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP--TYDAVVQMEYLDMVVNETLRL 366

  Fly   389 YPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQ 453
            :|....|:|.|......     ||   ..:..|:.|.|....:|.|.:||..||.|.||||| ::
Human   367 FPVAIRLERTCKKDVEI-----NG---VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KK 422

  Fly   454 RQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFV 513
            :....|..|.|||.|||.|||.....:.:|:.|:.:|.:|..:.|:.|...::.|.:..:
Human   423 KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	115/436 (26%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	124/475 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820