Protein Alignment Cyp6t1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_608457.1
• Gene: Cyp6t1 / 33127
• FlyBaseID: FBgn0031182
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 138/505 - (27%)
• Similarity: 245/505 - (48%)
• Gaps: 54/505 - (10%)

  Fly    17 LVLLP-VVLRGGCLLVVTIVWLWQILHFWH----WRRLGVPFVPAAPFVGNVWNLLRGACCFGDQ 76
            :.|:| :.:....||.|::|.|:  |:..|    :::||:|.....||:||:.:..:|.|.|..:
Human     1 MALIPDLAMETWLLLAVSLVLLY--LYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDME 63

  Fly    77 FRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVED-FAQFSSRFETTDPTCDTMG--SQ 138
            ..:.|      |:.: |........|.:.||.:||.::|:: ::.|::| ....|    :|  ..
Human    64 CHKKY------GKVW-GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR-RPFGP----VGFMKS 116

  Fly   139 NLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALF 203
            .:..::.|.|:....:.:|.|.:||::.|..::...|..|..::.::  ......:.:|.:...:
Human   117 AISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKDVFGAY 179

  Fly   204 TTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHL---------FTMF-FFPRLSHRV 258
            :.|:|.|.:||:...||.||:..|    :|    ..|:||..         .|:| |...:...:
Human   180 SMDVITSTSFGVNIDSLNNPQDPF----VE----NTKKLLRFDFLDPFFLSITVFPFLIPILEVL 236

  Fly   259 GTHLYSEEYERFMRKSMDYVLSQRAE-SGENRHDLIDIFLQLKRTEPAESIIHRPDF-FAAQAAF 321
            ...::..|...|:|||:..:...|.| :.::|.|.:.:.:..:.::..||.....|. ..||:..
Human   237 NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301

  Fly   322 LLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVL 386
            .:.||::|:||.::|.:||||.:..:|.:|:.|:.|.|.:....  :.|||..:.||..||:|.|
Human   302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP--TYDTVLQMEYLDMVVNETL 364

  Fly   387 RLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSA 451
            ||:|....|:|.|......     ||   ..:..|..|.|....:|||.:||..||.|.|||||.
Human   365 RLFPIAMRLERVCKKDVEI-----NG---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421

  Fly   452 EQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERT 501
            :.:....|..|.|||:|||.|||.....:.:|:.|:.:|.:|..:.|:.|
Human   422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	117/426 (27%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	127/465 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920