DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	552	Identity:	115/552 - (20%)
Similarity:	212/552 - (38%)	Gaps:	143/552 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LPVVLRGGCLLVVTIVWLWQILHFWHWRR----------LGV-PFVPAAPFVGNVWNLLRGACCF 73
            :|::|..|.||::           |:...          ||: |.:....|   :|..:..||
Mouse    26 MPLLLIMGLLLLI-----------WNCESSSSIPGPGYCLGIGPLISHGRF---LWMGIGSAC-- 74

  Fly    74 GDQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRF-ETTDPTCDTMGS 137
             :.:.::|..       |:.:.:.....|::...:.:..:|  ..:.:.||| ......|..|..
Mouse    75 -NYYNKMYGE-------FMRVWISGEETLIISKSSSMFHVM--KHSHYISRFGSKRGLQCIGMHE 129

  Fly   138 QNLFFSKYET-WRETHKIFAPFF-----AAGKVRNMYGLLENIGQKLEEHMEQKLSGRD-SMELE 195
            ..:.|:...: ||    ...|||     ..|.||    ::|...:.:::|:::.....| |..::
Mouse   130 NGIIFNNNPSLWR----TIRPFFMKALTGPGLVR----MVEVCVESIKQHLDRLGEVTDTSGYVD 186

  Fly   196 VKQLCALFTTDIIASLAFGI---EAHSLQNPEAEF---RRMCIEVNDPRPKRLLHLFTMFFFPRL 254
            |..|......|....|..||   |:..::..:..|   :.:.|:.|            :||  ::
Mouse   187 VLTLMRHIMLDTSNMLFLGIPLDESAIVKKIQGYFNAWQALLIKPN------------IFF--KI 237

  Fly   255 SHRVGTHLYSEEYERFMRKSMDYVL------SQRAESGENRHDLID-----IFLQ----LKRTEP 304
            |     .|| .:|||.::...|.:.      ..:..:.|...|.:|     ||.:    |.:...
Mouse   238 S-----WLY-RKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCMDFATDLIFAERRGDLTKENV 296

  Fly   305 AESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSC 369
            .:.|:.           :|:|..||.|.|:.|.|..:|:...::..:..|:...:   .||.:..
Mouse   297 NQCILE-----------MLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVV---GDRDIKI 347

  Fly   370 DTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRD 434
            :.:..|..:...::|.:|..|....:.|........|      |.|.|  .||.:.:::..:||
Mouse   348 EDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVID------GYPVK--KGTNIILNIGRMHR- 403

  Fly   435 AQYWPNPEVFDPERFSAEQRQQHHPMTYL-PFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEV- 497
            .:|:|.|..|..|.|     :::.|..|. |||.|||||.|..:..:.:||.|:.:|..|:|:.
Mouse   404 LEYFPKPNEFTLENF-----EKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTL 463

  Fly   498 ---C----------------ERTLPEMRFDPK 510
               |                :|.|.|:.|.|:
Mouse   464 QKRCIENIPKKNDLSLHPNEDRHLVEIIFSPR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	101/470 (21%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	105/510 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010