DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6t1 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	532	Identity:	121/532 - (22%)
Similarity:	209/532 - (39%)	Gaps:	111/532 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPA-APFVGNVWNLLR----GAC------CFG 74
            |.|:...||..:.::.||:    ....|..:|..|. .|.:|| ::|:.    |.|      .:|
Mouse     3 PFVVLVLCLSFMLLLSLWR----QRSARRNLPPGPTPLPIIGN-YHLIDMKDIGQCLTNFSKTYG 62

  Fly    75 DQFRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMG-SQ 138
            ..|...:.|:.        |.|||.:       ..||..:::....||.|  .:.|..|.:. .:
Mouse    63 PVFTLYFGSQP--------IVVLHGY-------EAIKEALIDHGEVFSGR--GSFPFFDKVSKGK 110

  Fly   139 NLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHME---QKLSGRDSMELEVKQLC 200
            .:.||....|:.|.     .|....:||:......|..|::|..:   ::|...:....:.:.:.
Mouse   111 GIGFSHGNVWKATR-----VFTVNTLRNLAMGKRTIENKVQEEAQWLMKELKKTNGSPCDPQFII 170

  Fly   201 ALFTTDIIASLAFGIEAHSLQN----PEAEFRRM------CIEVNDPRPKRLLHLFTMFFFPRLS 255
            .....::|.|:.|       ||    .:.:|..:      |.|:......::.:...:.    :.
Mouse   171 GCAPCNVICSIVF-------QNRFDYKDKDFLSLIGKVNECTEILSSPGCQIFNAVPIL----ID 224

  Fly   256 HRVGTHLYSEEYERFMRKS---MDYVLSQRAESGE-----NRHDLIDIFL-QLKRTEPAESIIHR 311
            :..|.|      .:|.:..   ..|:|.:..|..|     |..|.||.|| |.::.:..|.:.:.
Mouse   225 YCPGRH------NKFFKNHTWIKSYLLEKIKEHEESLDVTNPRDFIDYFLIQRRQDKGIEHMEYT 283

  Fly   312 PDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTEL-----RAALQSSQDRQLSCDT 371
            .:..|.....|:..|.:|.|||:.|||..|.|:|.|..:::.|:     |......|||:
Mouse   284 IEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRK----- 343

  Fly   372 VTGLVYLRQVVDEVLR---LYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHR 433
              .:.|...:|.||.|   |.|.:...:..|:::......|          .||.|..|:..:..
Mouse   344 --HMPYTNAMVHEVQRYVDLGPTSLVHEVTCDTKFRNYFIP----------KGTQVMTSLSSVLH 396

  Fly   434 DAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVC 498
            |:..:||||||||..|..:.........::||.||.|.|:|..|.::|:.:.|..||.:|:::..
Mouse   397 DSTEFPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPL 461

  Fly   499 ERTLPEMRFDPK 510
                    .|||
Mouse   462 --------VDPK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	103/451 (23%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	114/501 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010