DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6t1 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	554	Identity:	141/554 - (25%)
Similarity:	229/554 - (41%)	Gaps:	96/554 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IAAALAVGSLVLLPVVLRGGCLLVVTIVWLWQILHFWHWRRLGVPFVPAAPFVGNVWNLLRGACC 72
            ::..|.|.|::       |..||:|..|..:  || ..|....:...|:.||   .|       .
Mouse    15 LSGFLQVASVL-------GLLLLLVKAVQFY--LH-RKWLLKALQQFPSPPF---HW-------F 59

  Fly    73 FG-DQFRELYESKEAAGRA----------FVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFE 126
            || :||:...|.||.....          |.|    .|..|.:.||..:|.|:.....:.:..:.
Mouse    60 FGHEQFKGEQELKEVVSCIEHFPSAFPCWFWG----SNAYLTVYDPDYMKVILGRSDPKANGIYR 120

  Fly   127 TTDPTCDTMGSQNLFFSKYETWRETHKIFAPFF----AAGKVRNMYGLLENIGQKLEEHMEQKLS 187
            ...|..    ...|.....:.|.:..::..|.|    ....|:||...:..:..|.|     :|:
Mouse   121 LLAPWI----GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWE-----RLA 176

  Fly   188 GRDSMELEVKQLCALFTTDIIASLAFGIEAHSLQNPEAEFRRMCIEVND------PRPKRLLH-- 244
            |:|| .:|:.|..:|.|.|.:...||..:. |:| .:..::.....:.|      .|.:.:.|
Mouse   177 GQDS-SIEIFQHISLMTLDTVMKCAFSHKG-SVQ-VDGNYKTYLQAIGDLNNLFHSRVRNIFHQN 238

  Fly   245 --LFTMFFFPRLSHRVG--THLYSEEYERFMRKSMDYVLSQRAESGE-------NRHDLIDIFLQ 298
              ::.:....||:.:..  .|.:::...: |||      .|..:.||       .|.|.:||.|
Mouse   239 DTIYRLSSNGRLAKQACQLAHDHTDGVIK-MRK------DQLQDEGELENIKKKRRLDFLDILL- 295

  Fly   299 LKRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQ 363
            ..|.|..:|:..:.  ..|:....:..|.||::|.:::..|.||.:...|.|.|.|:::.|  ..
Mouse   296 FARMENGDSMSDKD--LRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLL--GD 356

  Fly   364 DRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISV 428
            ...::.|.:..:.|....:.|.||||||...:.|..::...:.    :|.|   |..|..|.:|:
Mouse   357 GSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFP----DGRS---LPKGVQVTLSI 414

  Fly   429 LGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHF 493
            .|:|.:.:.|||||||||.||:.:..:..|  ::|||..|.|.|||......|:||.:...|.||
Mouse   415 YGLHHNPKVWPNPEVFDPSRFAPDSPRHSH--SFLPFSGGARNCIGKQFAMSELKVIVALTLLHF 477

  Fly   494 RVEVCERTLPEMRFDPKA-FVLTAHNGTYLRFVK 526
            .:......:||    |.| .||.:.||.||...|
Mouse   478 ELLPDPTRVPE----PLARIVLKSKNGIYLHLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	113/447 (25%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	127/501 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010