DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir20a and Ir75b

DIOPT Version :9

Sequence 1:	NP_608456.1	Gene:	Ir20a / 33126	FlyBaseID:	FBgn0031181	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	104/530 - (19%)
Similarity:	172/530 - (32%)	Gaps:	179/530 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 EVAGPDQVTLARQYLSFCLRRSMLHVELYFRDYHHSLILYSFRAFPSFELVMRWISVGQGVKL-- 176
            ::.|...:|..|:.  || .::...||.|..:.:....|...::|..  |.||..:|...:.|
  Fly   145 QLGGELNITADREI--FC-NKTNCRVERYLSELYTRSALQHRKSFTG--LTMRATAVVTALPLNV 204

  Fly   177 FLHKLDDLRGHRLRVIPD----------------LSPPNTFFYRDARGDNQVT-GYLWDFLATFA 224
            .:.::.|....:.|:..|                |.....:.:||...|...| |.:.|.:
  Fly   205 SIKEIFDFMNSKYRIQLDTYARLGYQARQPLRDMLDCKFKYIFRDRWSDGNATGGMIGDLI---- 265

  Fly   225 GRLNAGLEVVRPSWRAGSASDSSYMLEYSAKGLIDVGLTTTLITKWNLW-AIHQYTYPLLVSSWC 288
              |:.....:.|             ..||    .|..|....|||:::: .|..:..|..||:..
  Fly   266 --LDKADLAIAP-------------FIYS----FDRALFLQPITKFSVFREICMFRNPRSVSAGL 311

  Fly   289 TMLPVEKPLATPDLFGRIVCPTLAMTLLLIILVTWLVFRQLRCLTRLKNSRPARIVPHLLTL--- 350
            :.....:|      |...|..|.|:.|||...:.|:.|    .|.|.|..:|:.:...||:.
  Fly   312 SATEFLQP------FSGGVWLTFALLLLLAGCLLWVTF----ILERRKQWKPSLLTSCLLSFGAG 366

  Fly   351 --------------------LLLTT-------CSAQLLSLL----------------------IF 366
                                |::|:       .|..:..||                      |.
  Fly   367 CIQGAWLTPRSMGGRMAFFALMVTSYLMYNYYTSIVVSKLLGQPIKSNIRTLQQLADSNLDVGIE 431

  Fly   367 PPYHVRI-------ASFEDLLRGDQKILGMRNEFYNFDGAFRARYAGVFYLIDDPNELYDLRNHF 424
            |..:.||       ....||.|  :|:||.:.   :.|..:....|||..:.|....:|
  Fly   432 PTVYTRIYVETSEEPDVRDLYR--KKVLGSKR---SPDKIWIPTEAGVLSVRDQEGFVY------ 485

  Fly   425 NTTWAYTMPYIKWLVIKTQQRHFSKPLFRWSKDLCFFDFMP------TSVIVAPDSIYWESIKDF 483
            .|..|....:::        :||      .:..:|..:.:|      |..::|..|.|.|.||..
  Fly   486 ITGVATGYEFVR--------KHF------LAHQICELNEIPLRDASHTHTVLAKRSPYAELIKLS 536

  Fly   484 TFRIHQAGL-MKH---WIRKSFY-----DMIKAGKMSIKDYSDLETLKPL------------NIG 527
            ..|:.:.|: .||   |:....:     ..:..|         ||...||            .|.
  Fly   537 ELRMLETGVHFKHERSWMETKLHCYQHNHTVAVG---------LEYAAPLFIILLGAIILCMGIL 592

  Fly   528 DLEIVW-RVC 536
            .||::| |.|
  Fly   593 GLEVIWHRHC 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir20a	NP_608456.1	None
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	71/357 (20%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	51/279 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100