DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-beta and Igsf9

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001139272.1	Gene:	Igsf9 / 93842	MGIID:	2135283	Length:	1179	Species:	Mus musculus

Alignment Length:	366	Identity:	87/366 - (23%)
Similarity:	132/366 - (36%)	Gaps:	117/366 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 CIDLTVSNKISSVGA---FEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKV-A 141
            |:.|||.:.|.|.||   .:|:.|    :|....|..|...|.:....||        .|..| .
Mouse     4 CLRLTVLSLIISQGADGRRKPEVV----SVVGRAGESAVLGCDLLPPAGH--------PPLHVIE 56

  Fly   142 WIKADAKAILAIHEHVITNNDRLSVQHNDY-------NTWTLNIRGVKMEDAGKYMCQ------- 192
            |::..  .:|.|.......:.|:.   .||       ...:|.|.|:::||.|.|.|:
Mouse    57 WLRFG--FLLPIFIQFGLYSPRID---PDYVGRVRLQTGASLQIEGLRVEDQGWYECRVLFLDQH 116

  Fly   193 ---------------VNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKP 242
                           ||:.|...:|       ||.::.        |.|..:..|.|.|||.|:|
Mouse   117 SPEQDFANGSWVHLTVNSPPQFQET-------PPLVLE--------VKELEAVTLRCVARGSPQP 166

  Fly   243 KITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQV 307
            .:||:.. |:::....|..|      |:...|.:.::.|...|.|.|.||:. ..:::...:|.|
Mouse   167 YVTWKFR-GQDLGKGQGQVQ------VQNGTLWIRRVERGSAGDYTCQASSS-EGSITHATQLLV 223

  Fly   308 HFHPLVQVP--NQLVGAPVLTDVTLICNVEASPKAINY-WQRENGEMIIAGDRYALTEKENNMYA 369
            ...|::.||  |..|.:.  .||:|.|..||.|..:.| |.::...
Mouse   224 LGPPVIVVPPSNSTVNSS--QDVSLACRAEAYPANLTYSWFQDGVN------------------- 267

  Fly   370 IEMILHIKRLQS-----------------SDFGGYKCISKN 393
               :.||.||||                 .|.|.|.|:..|
Mouse   268 ---VFHISRLQSRVRILVDGSLWLQATQPDDAGHYTCVPSN 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	28/140 (20%)
		ig	102..195	CDD:278476	23/122 (19%)
		IG_like	219..307	CDD:214653	23/87 (26%)
		Ig	221..307	CDD:299845	23/85 (27%)
		Ig	311..404	CDD:299845	25/103 (24%)
		IG_like	327..405	CDD:214653	20/85 (24%)
Igsf9	NP_001139272.1	IG_like	28..110	CDD:214653	22/94 (23%)
		Ig	136..223	CDD:386229	27/109 (25%)
		Ig_3	227..305	CDD:372822	24/101 (24%)
		Ig	341..404	CDD:386229
		Ig	436..500	CDD:319273
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..842
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..974
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810