DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and PAPLN

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	420	Identity:	88/420 - (20%)
Similarity:	137/420 - (32%)	Gaps:	180/420 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GSGLVGLGTGTGTGSGCGPAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQG 112
            ||...|||...|:     ||..:.             :.|.:||..|. ||..      |..|.|
Human   885 GSRAPGLGGDAGS-----PAPPFH-------------SSSYRISLAGV-EPSL------VQAALG 924

  Fly   113 RDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLN 177
            :....:|           .|.::..::.||.| |.:.|         ::||..:|.:.    :|.
Human   925 QLVRLSC-----------SDDTAPESQAAWQK-DGQPI---------SSDRHRLQFDG----SLI 964

  Fly   178 IRGVKMEDAGKYMC---QVNTDPMKMQTATLEVVIPPDIINEETSGDMMV--------------- 224
            |..::.||||.|.|   :...|..|:|   |.::          .|||.|
Human   965 IHPLQAEDAGTYSCGSTRPGRDSQKIQ---LRII----------GGDMAVLSEAELSRFPQPRDP 1016

  Fly   225 --------------------PE-------------------GGSAKLVCRARGHPKPKITWRRED 250
                                |:                   |...::.|||.|.|.|.|.|:| |
Human  1017 AQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQR-D 1080

  Fly   251 GREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASN--------------------GV 295
            |:.:  .:..||.....|     |.:|::...:.|.|.|:|.|                    |:
Human  1081 GQPV--SSPRHQLQPDGS-----LVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGL 1138

  Fly   296 PPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINY-WQRENGEMIIAGDRYA 359
            ||||:                     .|......|:|.|  :.:::|. |.| || :.:..|.:.
Human  1139 PPTVT---------------------VPEGDTARLLCVV--AGESVNIRWSR-NG-LPVQADGHR 1178

  Fly   360 LTEKENNMYAIEMILHIKRLQSSDFGGYKC 389
            :.:..:.      .|.|..|::.|.|.|.|
Human  1179 VHQSPDG------TLLIYNLRARDEGSYTC 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	26/113 (23%)
		ig	102..195	CDD:278476	21/95 (22%)
		IG_like	219..307	CDD:214653	32/161 (20%)
		Ig	221..307	CDD:299845	31/159 (19%)
		Ig	311..404	CDD:299845	17/80 (21%)
		IG_like	327..405	CDD:214653	16/64 (25%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767	8/37 (22%)
		Ig	914..>978	CDD:325142	22/95 (23%)
		I-set	1049..1119	CDD:254352	22/77 (29%)
		IG	1139..1219	CDD:214652	21/95 (22%)
		PLAC	1235..1267	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900