DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and PDCD1LG2

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_005251657.1	Gene:	PDCD1LG2 / 80380	HGNCID:	18731	Length:	283	Species:	Homo sapiens

Alignment Length:	218	Identity:	43/218 - (19%)
Similarity:	75/218 - (34%)	Gaps:	74/218 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSA 136
            ::.|||:     |::..::..:.|.. ...:|.|...|..|.:.|..|..:. |.|...|..:::
Human     1 MIFLLLM-----LSLELQLHQIAALF-TVTVPKELYIIEHGSNVTLECNFDT-GSHVNLGAITAS 58

  Fly   137 PAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTW----------TLNIRGVKMEDAGKYMC 191
            ..||                   .||  :..|.:..|.          :.:|..|::.|.|:|.|
Human    59 LQKV-------------------END--TSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQC 102

  Fly   192 ---------------QVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPK 241
                           :|.....|:.|..|:                 |||....:|.|:|.|:|.
Human   103 IIIYGVAWDYKYLTLKVKASYRKINTHILK-----------------VPETDEVELTCQATGYPL 150

  Fly   242 PKITWRREDGREIIARNGSHQKT 264
            .:::|....    :..|.||.:|
Human   151 AEVSWPNVS----VPANTSHSRT 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	25/135 (19%)
		ig	102..195	CDD:278476	22/117 (19%)
		IG_like	219..307	CDD:214653	13/46 (28%)
		Ig	221..307	CDD:299845	13/44 (30%)
		Ig	311..404	CDD:299845
		IG_like	327..405	CDD:214653
PDCD1LG2	XP_005251657.1	Ig	26..>103	CDD:299845	20/98 (20%)
		IG_like	35..119	CDD:214653	18/105 (17%)
		Ig	137..193	CDD:299845	10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910