DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	157/380 - (41%)
Similarity:	222/380 - (58%)	Gaps:	43/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LEIASGSGLVGLG--------TGTGTGSGCGPAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPD 99
            ||..|....||||        ..|.|||. |.|           ||....|::|.||.    :|:
  Fly     5 LEAISSFLYVGLGCLIASSVALSTDTGSE-GNA-----------GNVGGSTLNNVISE----DPE 53

  Fly   100 FVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRL 164
            |...:||:|:..||:....|.|.|||.:           ||||:..:..|||.:|.||||.|.|:
  Fly    54 FTDVIENITVPAGRNVKLACSVKNLGSY-----------KVAWMHFEQSAILTVHNHVITRNPRI 107

  Fly   165 SV---QHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPE 226
            ||   :|:.:.||.|:|..|:.||.|:||||:||...|.|...::||:||:|.:..||.|::|.|
  Fly   108 SVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTSSDIIVRE 172

  Fly   227 GGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIA 291
            |.:..|.|:|:|.|:|.|.|:|:||.:|:.    ::..:...:|.:.|.|.:|:|..||||:|||
  Fly   173 GDNVTLRCKAKGSPEPTIKWKRDDGNKIVI----NKTLEVHDLETDSLELERISRLHMGAYLCIA 233

  Fly   292 SNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGD 356
            ||||||:||||:|:.|.|.|:|.:|:||||.|:..::||.|.:||:|.::|||.|||.:||....
  Fly   234 SNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESS 298

  Fly   357 RYAL-TEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERP 410
            :|.. |...:..|...|.|.|..:||||:|.|||::||..||.:|.|:||....|
  Fly   299 KYKTETIPGHPSYKATMRLTITNVQSSDYGNYKCVAKNPRGDMDGNIKLYMSSPP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	46/113 (41%)
		ig	102..195	CDD:278476	39/95 (41%)
		IG_like	219..307	CDD:214653	40/87 (46%)
		Ig	221..307	CDD:299845	39/85 (46%)
		Ig	311..404	CDD:299845	42/93 (45%)
		IG_like	327..405	CDD:214653	34/78 (44%)
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	44/106 (42%)
		Ig	69..139	CDD:143165	33/80 (41%)
		IG_like	165..249	CDD:214653	40/87 (46%)
		IGc2	172..237	CDD:197706	28/68 (41%)
		IG_like	267..348	CDD:214653	34/80 (43%)
		Ig	270..339	CDD:299845	30/68 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442807
Domainoid	1	1.000	48	1.000	Domainoid score	I11903
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	10	9.900