DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-beta and BTN1A1

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001723.2	Gene:	BTN1A1 / 696	HGNCID:	1135	Length:	526	Species:	Homo sapiens

Alignment Length:	485	Identity:	93/485 - (19%)
Similarity:	163/485 - (33%)	Gaps:	155/485 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSA 136
            ||.|:||          ::..:.:...|.:.|.|.:....|.||...|        |:|.:.|:.
Human    13 LLTLILL----------QLPKLDSAPFDVIGPPEPILAVVGEDAELPC--------RLSPNASAE 59

  Fly   137 PAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDY-------------NTWTLNIRGVKMEDAGK 188
            ..::.|.:......:.:|.   ...::.:.|..:|             ....|.||||::.|.|:
Human    60 HLELRWFRKKVSPAVLVHR---DGREQEAEQMPEYRGRATLVQDGIAKGRVALRIRGVRVSDDGE 121

  Fly   189 YMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARG-HPKPKITWRREDGR 252
            |.|....|. ..:.|.:.:.:.  .:..:....|.|.|.|...|.|.:.| :|:|::.||...|.
Human   122 YTCFFREDG-SYEEALVHLKVA--ALGSDPHISMQVQENGEICLECTSVGWYPEPQVQWRTSKGE 183

  Fly   253 EIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPN 317
            :..:.:.|...                  .|.|.:...||..:..|.:|.:...:.        |
Human   184 KFPSTSESRNP------------------DEEGLFTVAASVIIRDTSAKNVSCYIQ--------N 222

  Fly   318 QLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSS 382
            .|:|.....::::   ..:|...:..|                      :.|:.:||.:..|.
Human   223 LLLGQEKKVEISI---PASSLPRLTPW----------------------IVAVAVILMVLGLL-- 260

  Fly   383 DFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRN-LNGRL 446
                       :||....|.|||. |||.::      .||.|..|.:.::.:.:..:.: ::..|
Human   261 -----------TIGSIFFTWRLYN-ERPRER------RNEFSSKERLLEELKWKKATLHAVDVTL 307

  Fly   447 YKDRAPDQHPASGSDQLLGRGTMRLIGTFLLALLVLFTALAEAGPTTLSCRTKGGRQKKAKET-- 509
            ..|.|   ||.                      |.|:       ..:.|.|.:..|||..::|
Human   308 DPDTA---HPH----------------------LFLY-------EDSKSVRLEDSRQKLPEKTER 340

  Fly   510 --SWN---GRRA-RDGR-----EDGHAAEW 528
              ||.   ||.. ..||     |.|...:|
Human   341 FDSWPCVLGRETFTSGRHYWEVEVGDRTDW 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	25/123 (20%)
		ig	102..195	CDD:278476	22/105 (21%)
		IG_like	219..307	CDD:214653	19/88 (22%)
		Ig	221..307	CDD:299845	19/86 (22%)
		Ig	311..404	CDD:299845	12/92 (13%)
		IG_like	327..405	CDD:214653	10/77 (13%)
BTN1A1	NP_001723.2	IG_like	35..141	CDD:214653	23/117 (20%)
		Ig_MOG_like	43..142	CDD:143190	22/110 (20%)
		Ig	162..223	CDD:299845	15/86 (17%)
		SPRY_PRY_BTN1_2	302..473	CDD:293991	22/101 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910