DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and IGSF9

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	263	Identity:	64/263 - (24%)
Similarity:	96/263 - (36%)	Gaps:	89/263 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 TLNIRGVKMEDAGKYMCQ----------------------VNTDPMKMQTATLEVVIPPDIINEE 217
            :|.|.|:::||.|.|.|:                      ||:.|...:|       ||.::.
Human    92 SLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQET-------PPAVLE-- 147

  Fly   218 TSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRS 282
                  |.|.....|.|.|||.|.|.:||:.. |:::....|..|      |:...|.:.::.|.
Human   148 ------VQELEPVTLRCVARGSPLPHVTWKLR-GKDLGQGQGQVQ------VQNGTLRIRRVERG 199

  Fly   283 EMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVP--NQLVGAPVLTDVTLICNVEASPKAINY-W 344
            ..|.|.|.||: ...:.:...:|.|...|::.||  |..|.|.  .||:|.|:.||.|..:.| |
Human   200 SSGVYTCQASS-TEGSATHATQLLVLGPPVIVVPPKNSTVNAS--QDVSLACHAEAYPANLTYSW 261

  Fly   345 QRENGEMIIAGDRYALTEKENNMYAIEMILHIKRL-----------------QSSDFGGYKCISK 392
            .::|..                      :.||.||                 |..|.|.|.|:..
Human   262 FQDNIN----------------------VFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPS 304

  Fly   393 NSI 395
            |.:
Human   305 NGL 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	12/55 (22%)
		ig	102..195	CDD:278476	9/41 (22%)
		IG_like	219..307	CDD:214653	23/87 (26%)
		Ig	221..307	CDD:299845	23/85 (27%)
		Ig	311..404	CDD:299845	26/105 (25%)
		IG_like	327..405	CDD:214653	20/87 (23%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	8/39 (21%)
		IG_like	28..110	CDD:214653	8/17 (47%)
		I-set	136..223	CDD:254352	27/109 (25%)
		Ig	154..220	CDD:143165	20/73 (27%)
		Ig_3	226..305	CDD:290638	25/102 (25%)
		IG_like	233..319	CDD:214653	23/99 (23%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810