DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and ush2a

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	407	Identity:	84/407 - (20%)
Similarity:	129/407 - (31%)	Gaps:	132/407 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 DYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINE-------ETSG--DMMVP 225
            :|..|.:|..|    .||....|.:|.|           .||:.|:.       .||.  |:..|
Zfish  4735 EYQVWAVNSAG----RAGSPWAQGHTGP-----------APPEGISSPKFLYIYSTSAVVDISPP 4784

  Fly   226 EGGSAKLVCRARGHPKP-------KITWRREDGREIIARNGSHQKT-------KAQSVEGEMLT- 275
                          .||       ::..:.:|..::::...|||:|       ...||..|:.|
Zfish  4785 --------------TKPNGIISLYRVFAQNKDSYQLLSEGTSHQQTLHGLRPFTVYSVGVEVCTC 4835

  Fly   276 ---LSKITRSEMGAYMCIASNGVPP---TVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNV 334
               .|:...||:.......:...||   .::.|..|.....||  .||.::.:..| .|.|.|..
Zfish  4836 FLCCSRGPLSELRTQASAPAQQPPPRPIALTSRSALVEWDMPL--QPNGIIESCEL-QVRLSCPQ 4897

  Fly   335 EASP------------KAINYWQRENGEMIIAGDRYAL-------------------TEKENNMY 368
            ...|            |.....|..|...::....|.|                   |.||...|
Zfish  4898 PPQPVPVPCAIGPVEVKFFGMGQSFNISGLLPYANYELCVVSYNNMGSTASDWVSITTLKEPPQY 4962

  Fly   369 AIEMILHIKRLQ-----SSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDL-------- 420
            ....::|.....     |..|.....:::.|:  ||.::|:|........|.|..|.
Zfish  4963 MEAFVVHSNLTSVFVDWSGSFSLNGPLTEYSL--TESSLRVYSGFHSFLHIPRTSDKTFAFQVTC 5025

  Fly   421 ---NEVSKNEVVQKDT--------RSEDGSRNLNGRLYKDRAPDQHPASGSDQLLGRGTMRLIGT 474
               :..:.:.|::.:|        .|..|...|.|..||...          :|.....|.|:|.
Zfish  5026 TTDSGSASSPVIKYNTATGIDAVESSSGGKTGLYGSEYKFYT----------ELWFIILMALVGL 5080

  Fly   475 FLLAL---LVLFTALAE 488
            .||||   |||..||::
Zfish  5081 LLLALLMGLVLKRALSK 5097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	9/38 (24%)
		ig	102..195	CDD:278476	7/24 (29%)
		IG_like	219..307	CDD:214653	21/110 (19%)
		Ig	221..307	CDD:299845	20/106 (19%)
		Ig	311..404	CDD:299845	24/128 (19%)
		IG_like	327..405	CDD:214653	20/113 (18%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470
		FN3	4382..4465	CDD:238020
		FN3	4470..4553	CDD:238020
		FN3	4555..4653	CDD:238020
		FN3	4679..4753	CDD:238020	6/21 (29%)
		fn3	4760..4830	CDD:278470	16/83 (19%)
		FN3	4864..4955	CDD:238020	16/93 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900