DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and aebp1b

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	414	Identity:	74/414 - (17%)
Similarity:	145/414 - (35%)	Gaps:	106/414 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLS 165
            :|| ...||..|:.....|        :||.|..:    :.|:..:.       |.|:|.:..|.
Zfish    60 IIP-PYATIEVGQHKQLLC--------KVSSDAKN----INWVSPNG-------EKVLTKHGNLK 104

  Fly   166 VQHNDYNTWTLNIRGVKMEDAGKYMC-QVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGS 229
            |.::.....:|.:....:.:||.|.| ..|.|.....|..|::::..  :..:|.      ..|.
Zfish   105 VHNHGSVLSSLTVLNANLNNAGIYKCVATNGDTESQATVKLDIILKR--MRRDTD------RKGR 161

  Fly   230 AKLVCRARGHPKPKI---TWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIA 291
            .|.:...:...|||.   |.:.:..::.....|..:|.|....|.                ..:|
Zfish   162 EKRLKEPKPSKKPKASKPTKKPKSEKKGKGEKGGKKKGKKNREES----------------TTVA 210

  Fly   292 SNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASP------------------ 338
            :..|.||.:..|:.:..:.|   .|:|........:.|.:.....:|
Zfish   211 TTTVAPTTTVPMEYEEFYDP---EPDQYWDEDFPAETTTVARTTTTPTEKTKDFIPDMDEYSQPD 272

  Fly   339 KAINYWQREN---GEMIIAGDRYALTEKENNMYAIEMILHI-----KRLQSSDFG-GYKCISKNS 394
            ...:||:.:.   ...:||| |.|..:...:..::||:.::     |.:.|:|.. .|....:.:
Zfish   273 SYDDYWKVDEPTPTTSVIAG-RPADDDDYWDARSVEMVENLPFPDGKEISSTDNDWQYTTTEEPT 336

  Fly   395 IGDTEGT-IRLYE------MERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKD--- 449
            :...|.: ...||      :|...:::.::.:..|..:.:.::::.|..        |:|:.
Zfish   337 VPPFENSWYEEYEYGHEKKLEEERERLRKEQEEKEREERKRLEEEERER--------RIYRPPPR 393

  Fly   450 --RAPDQHPASG-------SDQLL 464
              |.|...|..|       :||||
Zfish   394 VYREPKICPPLGMESHRIDNDQLL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	24/108 (22%)
		ig	102..195	CDD:278476	20/93 (22%)
		IG_like	219..307	CDD:214653	15/90 (17%)
		Ig	221..307	CDD:299845	15/88 (17%)
		Ig	311..404	CDD:299845	19/120 (16%)
		IG_like	327..405	CDD:214653	16/105 (15%)
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	24/106 (23%)
		IG_like	62..145	CDD:214653	22/102 (22%)
		FA58C	402..555	CDD:238014	6/16 (38%)
		FA58C	403..556	CDD:214572	5/15 (33%)
		Peptidase_M14_like	577..1036	CDD:299699
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900