DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and PSG1

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001284702.1	Gene:	PSG1 / 5669	HGNCID:	9514	Length:	428	Species:	Homo sapiens

Alignment Length:	391	Identity:	84/391 - (21%)
Similarity:	136/391 - (34%)	Gaps:	94/391 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GTGTGSGCGPAIRWQ-LLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCV 120
            ||.:...|...|:|: |||...|.|..:|..:.:::          |..|...:::|:|...  :
Human     2 GTLSAPPCTQRIKWKGLLLTASLLNFWNLPTTAQVT----------IEAEPTKVSEGKDVLL--L 54

  Fly   121 VNNLGGHRVSGDGSSAPAKVAWIKADAKAI------LAIHEHVITNNDRLSVQHNDYNTWTLNIR 179
            |:|| ...::|        ..|.|...:.:      ..:...:|......|.:...|:..:|.|:
Human    55 VHNL-PQNLTG--------YIWYKGQMRDLYHYITSYVVDGEIIIYGPAYSGRETAYSNASLLIQ 110

  Fly   180 GVKMEDAGKYMCQV--NTDPMKMQTA----TLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARG 238
            .|..||||.|...:  ..|..:..|.    ||.:..|...|:..........|  :..|.|....
Human   111 NVTREDAGSYTLHIIKGDDGTRGVTGRFTFTLHLETPKPSISSSNLNPRETME--AVSLTCDPET 173

  Fly   239 HPKPKITWRREDGREIIARNG-----SHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPT 298
            .....:.|          .||     :|....:::  ...|.|..:|:...|.|.|...|.|..:
Human   174 PDASYLWW----------MNGQSLPMTHSLKLSET--NRTLFLLGVTKYTAGPYECEIRNPVSAS 226

  Fly   299 VSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTL-------ICNVEASPKAINY----WQRENGEMI 352
            .|..:.|.:    |.::|.     |.:|...|       :.|....||:.||    |.  ||:.:
Human   227 RSDPVTLNL----LPKLPK-----PYITINNLNPRENKDVLNFTCEPKSENYTYIWWL--NGQSL 280

  Fly   353 IAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIR--------LYEMER 409
            ....| .....||.      ||.:..:..::.|.|:|    .|.|..|.||        ||..:.
Human   281 PVSPR-VKRPIENR------ILILPSVTRNETGPYQC----EIRDRYGGIRSDPVTLNVLYGPDL 334

  Fly   410 P 410
            |
Human   335 P 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	25/122 (20%)
		ig	102..195	CDD:278476	21/100 (21%)
		IG_like	219..307	CDD:214653	17/92 (18%)
		Ig	221..307	CDD:299845	17/90 (19%)
		Ig	311..404	CDD:299845	26/111 (23%)
		IG_like	327..405	CDD:214653	22/96 (23%)
PSG1	NP_001284702.1	Ig_CEACAM_D1	36..138	CDD:143251	23/122 (19%)
		IG_like	41..>121	CDD:214653	19/90 (21%)
		Ig	148..236	CDD:299845	18/105 (17%)
		IG_like	163..221	CDD:214653	13/71 (18%)
		Ig	241..329	CDD:299845	24/105 (23%)
		IG_like	256..328	CDD:214653	21/84 (25%)
		Ig_2	335..413	CDD:290606	1/1 (100%)
		IG_like	339..413	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000