DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and robo4

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	397	Identity:	87/397 - (21%)
Similarity:	147/397 - (37%)	Gaps:	103/397 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWI-------- 143
            |..:|.:..  |..|....:|.:..|..||.:|          ..:|:..|. :.|:
Zfish    62 SRLVSEINL--PRIVHHPSDVVVRVGSPATLSC----------RAEGNPEPT-IQWLRNGQPLDT 113

  Fly   144 -KADAKAILAI-------------------HEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGK 188
             |.||::...:                   ||.|..     .:.||       :|......:|..
Zfish   114 DKMDAQSQPIVLPDGSLFFFSVVPGRKGQSHEAVYA-----CIAHN-------SIGNATSRNASL 166

  Fly   189 YMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRAR-GHPKPKITWRREDGR 252
            ::..:..| .::|.:.:||.|          |:|       |.:.|... |||:|.:|||: ||.
Zfish   167 HIAALRED-FRVQPSDVEVAI----------GEM-------ATINCSPPVGHPEPNVTWRK-DGI 212

  Fly   253 EIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPN 317
            .|.:.|..:.:.|.:      |.::...:::.|.|.|||||.:....|:..:|.|...|::....
Zfish   213 LINSSNEHYTELKGK------LIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKP 271

  Fly   318 QLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAI--EMILHIKRLQ 380
            :.|...:.......|..:..|.....|.||.|.:            .|..|.|  :..|.|..:.
Zfish   272 EDVSVQLGESAQFFCEADGDPMPSIEWSREQGPL------------PNGRYLINPDHSLQIHYVT 324

  Fly   381 SSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRD--DDLN--EVSKNEVVQKDTRSEDGSRN 441
            :.|.|.|.|..:|.:|.:..:.:|. :|..|...|||  .:|:  .||...|....|.|     |
Zfish   325 AQDMGRYSCTVENKLGVSVASAQLL-VEDAGGTRLRDLHKELSALRVSLENVTVMSTAS-----N 383

  Fly   442 LNGRLYK 448
            ::..::|
Zfish   384 MSQVMWK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	24/138 (17%)
		ig	102..195	CDD:278476	18/120 (15%)
		IG_like	219..307	CDD:214653	26/88 (30%)
		Ig	221..307	CDD:299845	25/86 (29%)
		Ig	311..404	CDD:299845	19/94 (20%)
		IG_like	327..405	CDD:214653	17/79 (22%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	20/123 (16%)
		I-set	71..168	CDD:254352	20/119 (17%)
		I-set	175..261	CDD:254352	30/109 (28%)
		Ig2_Robo	177..261	CDD:143201	30/107 (28%)
		I-set	265..350	CDD:254352	20/97 (21%)
		Ig	282..350	CDD:299845	18/80 (23%)
		FN3	373..448	CDD:214495	5/23 (22%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900