DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-beta and CNTN3

DIOPT Version :9

Sequence 1:NP_001138225.1 Gene:DIP-beta / 33125 FlyBaseID:FBgn0259245 Length:555 Species:Drosophila melanogaster
Sequence 2:NP_001380305.1 Gene:CNTN3 / 5067 HGNCID:2173 Length:1028 Species:Homo sapiens


Alignment Length:490 Identity:112/490 - (22%)
Similarity:182/490 - (37%) Gaps:113/490 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 PAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRD---ATFTCVVNNLGGH 127
            |..|||     |.|:.||:::.::....|.         ..|.|...|:   .|:.|...|..|.
Human    58 PHYRWQ-----LNGSDIDMSMEHRYKLNGG---------NLVVINPNRNWDTGTYQCFATNSLGT 108

  Fly   128 RVSGDGSSAPAKVAWIKADAKAILAIHE--HVI------TNNDRLSVQ--HNDY----------- 171
            .||.:.....|.:...|...::.:::.|  .|:      .::..||..  .|:|           
Human   109 IVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRF 173

  Fly   172 ---NTWTLNIRGVKMEDAGKYMCQVN---TDPMKMQTATLEVVIPPDIINE-ETSGDMMVPE--- 226
               .|..|.|..|:..|.|.|.|.|.   |:...:.:.|..|:....::.| |...::..||   
Human   174 VSQETGHLYISKVEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLP 238

  Fly   227 ---GGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYM 288
               |.:.||.|.|.|:|.|:|.|||.||...      ..|.|.:...| :|.:....:.:.|:|.
Human   239 AAKGSTVKLECFALGNPIPQINWRRSDGLPF------SSKIKLRKFSG-VLEIPNFQQEDAGSYE 296

  Fly   289 CIASNGVPPTVSKRMKLQVHFHP-LVQVPNQLVGAPVLTDVTLI--------CNVEASPKAINYW 344
            |||.|.....|: |.:|..:..| .||         ::.||.:.        |.....||....|
Human   297 CIAENSRGKNVA-RGRLTYYAKPHWVQ---------LIKDVEIAVEDSLYWECRASGKPKPSYRW 351

  Fly   345 QRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEM-- 407
            .: ||..::..:|   |:.||.      .|.|..|..:|.|.::||::|..|....:..|..:  
Human   352 LK-NGAALVLEER---TQIENG------ALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVAS 406

  Fly   408 -----ERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKDRAPDQHPASGSDQLLGRG 467
                 :.|.||::      :|....:|..|.:.....|.|:.....|.:..:|...   .||..|
Human   407 APDFSKNPMKKLV------QVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERI---SLLNDG 462

  Fly   468 TMRLIGTFLLALLVLFTALAEAGPTTLSCRTKGGR 502
            .:::..          ...|:||..|.....:.|:
Human   463 GLKIAN----------VTKADAGTYTCMAENQFGK 487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-betaNP_001138225.1 I-set 98..209 CDD:254352 29/140 (21%)
ig 102..195 CDD:278476 26/122 (21%)
IG_like 219..307 CDD:214653 29/93 (31%)
Ig 221..307 CDD:299845 29/91 (32%)
Ig 311..404 CDD:299845 24/101 (24%)
IG_like 327..405 CDD:214653 21/85 (25%)
CNTN3NP_001380305.1 Ig 25..120 CDD:416386 18/75 (24%)
Ig strand A 27..31 CDD:409353
Ig strand A' 34..39 CDD:409353
Ig strand B 45..53 CDD:409353
Ig strand C 58..64 CDD:409353 4/10 (40%)
Ig strand C' 66..69 CDD:409353 1/2 (50%)
Ig strand D 76..80 CDD:409353 0/3 (0%)
Ig strand E 82..88 CDD:409353 1/14 (7%)
Ig strand F 95..104 CDD:409353 2/8 (25%)
Ig strand G 107..120 CDD:409353 3/12 (25%)
Ig 129..214 CDD:416386 17/84 (20%)
Ig strand A 130..135 CDD:409353 0/4 (0%)
Ig strand B 139..145 CDD:409353 1/5 (20%)
Ig strand C 153..159 CDD:409353 2/5 (40%)
Ig strand C' 164..166 CDD:409353 0/1 (0%)
Ig strand D 171..176 CDD:409353 0/4 (0%)
Ig strand E 179..183 CDD:409353 1/3 (33%)
Ig strand F 193..201 CDD:409353 3/7 (43%)
Ig strand G 203..214 CDD:409353 2/10 (20%)
Ig 227..315 CDD:416386 29/95 (31%)
Ig strand A 227..232 CDD:409353 0/4 (0%)
Ig strand A' 235..240 CDD:409353 1/4 (25%)
Ig strand B 243..252 CDD:409353 3/8 (38%)
Ig strand C 258..262 CDD:409353 1/3 (33%)
Ig strand C' 265..267 CDD:409353 1/1 (100%)
Ig strand D 276..279 CDD:409353 0/2 (0%)
Ig strand E 280..285 CDD:409353 2/5 (40%)
Ig strand F 293..301 CDD:409353 5/7 (71%)
Ig strand G 304..315 CDD:409353 3/11 (27%)
Ig 320..403 CDD:416386 24/101 (24%)
Ig strand A' 326..330 CDD:409353 2/3 (67%)
Ig strand B 334..342 CDD:409353 1/7 (14%)
Ig strand C 348..353 CDD:409353 1/4 (25%)
Ig strand C' 355..358 CDD:409353 1/2 (50%)
Ig strand D 363..367 CDD:409353 2/6 (33%)
Ig strand E 369..374 CDD:409353 1/10 (10%)
Ig strand F 383..390 CDD:409353 2/6 (33%)
Ig strand G 394..403 CDD:409353 1/8 (13%)
Ig 408..496 CDD:416386 18/99 (18%)
Ig strand A 408..413 CDD:409353 0/4 (0%)
Ig strand A' 416..421 CDD:409353 2/10 (20%)
Ig strand B 425..432 CDD:409353 2/6 (33%)
Ig strand C 440..444 CDD:409353 1/3 (33%)
Ig strand D 458..461 CDD:409353 2/2 (100%)
Ig strand E 462..467 CDD:409353 1/4 (25%)
Ig strand F 475..483 CDD:409353 2/7 (29%)
Ig strand G 489..496 CDD:409353
Ig 498..598 CDD:416386
Ig strand A 498..504 CDD:409353
Ig strand A' 507..512 CDD:409353
Ig strand B 515..523 CDD:409353
Ig strand C 532..536 CDD:409353
Ig strand E 560..564 CDD:409353
Ig strand F 573..580 CDD:409353
Ig strand G 587..591 CDD:409353
FN3 598..695 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..713
FN3 703..795 CDD:238020
FN3 805..898 CDD:238020
FN3 906..991 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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