DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-beta and NCAM2

DIOPT Version :10

Sequence 1:NP_001138225.1 Gene:DIP-beta / 33125 FlyBaseID:FBgn0259245 Length:555 Species:Drosophila melanogaster
Sequence 2:XP_011527877.1 Gene:NCAM2 / 4685 HGNCID:7657 Length:874 Species:Homo sapiens


Alignment Length:629 Identity:139/629 - (22%)
Similarity:217/629 - (34%) Gaps:225/629 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 SGCGPAIRW-----------QLLLLLLLGNCIDLTVSNKISSVGAF----------EPDF--VIP 103
            |...||:.|           .....:|..|.:.:...|| |..|.:          |.||  :|.
Human   165 SSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINK-SDEGIYRCEGRVEARGEIDFRDIIV 228

  Fly   104 LENV-------------TIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHE 155
            :.||             |..:|.:.||:|        |.|  ||..|| ::|.:           
Human   229 IVNVPPAISMPQKSFNATAERGEEMTFSC--------RAS--GSPEPA-ISWFR----------- 271

  Fly   156 HVITNNDRLSVQHNDY-----NTWTLNIRGVKMEDAGKYMCQ-VNTDPMKMQTATLEVVIPPDII 214
                 |.:|..::..|     || .|.:|.:...|.|.|:|: .|......:.|.|:|.:.|.||
Human   272 -----NGKLIEENEKYILKGSNT-ELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHII 330

  Fly   215 ---NEETSGDMMVPEGGSAKLVCRARGHPKPKITWRRE-------------DGR-EIIARNGSHQ 262
               ||.|.      |.|...|||.|.|.|.|:|||:|.             ||| |:..::||  
Human   331 QLKNETTY------ENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGS-- 387

  Fly   263 KTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLV-----GA 322
                     ..|.:..:..|:.|.|.|.|::.:... .|.|.|.:.:.|.. :.||.:     |.
Human   388 ---------SSLHIKDVKLSDSGRYDCEAASRIGGH-QKSMYLDIEYAPKF-ISNQTIYYSWEGN 441

  Fly   323 PVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKEN---NMYAI--EMILHIKRLQSS 382
            |    :.:.|:|:::|.|..:|:|         |:..|..|..   ..|:.  :|||.|.....:
Human   442 P----INISCDVKSNPPASIHWRR---------DKLVLPAKNTTNLKTYSTGRKMILEIAPTSDN 493

  Fly   383 DFGGYKCISKNSIG-------------------------------------DTEGTIRLYEMERP 410
            |||.|.|.:.|.||                                     |:.|.:.::..:..
Human   494 DFGRYNCTATNHIGTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSHGGVPIHHYQVD 558

  Fly   411 GK-------KILRDDDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKDRA---------------PD 453
            .|       ||:|...:..:.....::.:|..|.....:||:...|.:               |.
Human   559 VKEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPS 623

  Fly   454 QH--PASGSDQLLGRGTMRLIGTFLLALLVLFTALAEAGPTTLSCRTKGGRQKKAKETSWNGRRA 516
            .|  |:||.             :|.|::    |...:.|...|....|  .:.|.||..|..::.
Human   624 IHGQPSSGK-------------SFKLSI----TKQDDGGAPILEYIVK--YRSKDKEDQWLEKKV 669

  Fly   517 RDGREDGHAAE---WRQCWERSALSWRR-----------SAPPE 546
            : |.:|....|   |...:|....:..|           |.||:
Human   670 Q-GNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYEFSMPPK 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-betaNP_001138225.1 Ig 98..209 CDD:472250 32/131 (24%)
Ig strand B 115..119 CDD:409353 2/3 (67%)
Ig strand C 139..143 CDD:409353 0/3 (0%)
Ig strand E 174..178 CDD:409353 1/3 (33%)
Ig strand F 188..193 CDD:409353 2/5 (40%)
Ig strand G 202..205 CDD:409353 1/2 (50%)
Ig 211..307 CDD:472250 34/112 (30%)
Ig strand B 230..234 CDD:409353 1/3 (33%)
Ig strand C 243..247 CDD:409353 2/3 (67%)
Ig strand E 272..276 CDD:409353 1/3 (33%)
Ig strand F 286..291 CDD:409353 2/4 (50%)
Ig strand G 300..303 CDD:409353 1/2 (50%)
IG_like 327..405 CDD:214653 24/119 (20%)
Ig strand B 328..332 CDD:409353 0/3 (0%)
Ig strand C 341..346 CDD:409353 1/4 (25%)
Ig strand E 365..376 CDD:409353 4/15 (27%)
Ig strand F 386..391 CDD:409353 2/4 (50%)
Ig strand G 399..402 CDD:409353 1/2 (50%)
NCAM2XP_011527877.1 IgI_1_NCAM-2 46..138 CDD:409452
Ig strand A 46..51 CDD:409452
Ig strand A' 54..58 CDD:409452
Ig strand B 60..70 CDD:409452
Ig strand C 74..80 CDD:409452
Ig strand C' 83..85 CDD:409452
Ig strand D 91..97 CDD:409452
Ig strand E 99..107 CDD:409452
Ig strand F 114..121 CDD:409452
Ig strand G 126..137 CDD:409452
Ig 142..218 CDD:472250 10/53 (19%)
Ig strand C 170..174 CDD:409353 1/3 (33%)
Ig strand E 193..197 CDD:409353 1/3 (33%)
IgI_1_MuSK 234..323 CDD:409562 26/116 (22%)
Ig strand A 234..237 CDD:409562 0/2 (0%)
Ig strand A' 242..247 CDD:409562 0/4 (0%)
Ig strand B 253..260 CDD:409562 4/14 (29%)
Ig strand C 266..271 CDD:409562 2/5 (40%)
Ig strand C' 273..275 CDD:409562 0/1 (0%)
Ig strand D 282..285 CDD:409562 1/2 (50%)
Ig strand E 289..295 CDD:409562 2/6 (33%)
Ig strand F 302..309 CDD:409562 3/6 (50%)
Ig strand G 315..323 CDD:409562 2/7 (29%)
IgI_NCAM-2 325..422 CDD:143278 34/114 (30%)
Ig strand A 325..330 CDD:143278 1/4 (25%)
Ig strand A' 334..338 CDD:143278 2/3 (67%)
Ig strand B 342..350 CDD:143278 3/7 (43%)
Ig strand C 356..362 CDD:143278 3/5 (60%)
Ig strand C' 365..368 CDD:143278 0/2 (0%)
Ig strand D 378..384 CDD:143278 2/5 (40%)
Ig strand E 387..393 CDD:143278 2/16 (13%)
Ig strand F 401..409 CDD:143278 4/7 (57%)
Ig strand G 412..422 CDD:143278 3/10 (30%)
Ig_3 426..504 CDD:464046 24/91 (26%)
FN3 521..613 CDD:238020 11/91 (12%)
fn3 619..703 CDD:394996 21/103 (20%)
Blue background indicates that the domain is not in the aligned region.

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