DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and opcml

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001005580.1	Gene:	opcml / 449538	ZFINID:	ZDB-GENE-040927-3	Length:	342	Species:	Danio rerio

Alignment Length:	328	Identity:	87/328 - (26%)
Similarity:	142/328 - (43%)	Gaps:	64/328 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 FVIPL------------ENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILA 152
            |::|.            :|:|:.||..|...|.::|    :||        :|||:  :...||
Zfish    23 FLVPAGVPARSGDSYLKDNITVRQGDSAVLKCSMDN----KVS--------RVAWL--NRTTIL- 72

  Fly   153 IHEHVITNNDRLSVQ------HNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTAT-LEVVIP 210
                 .|.|::.|:.      :...|.:::.|..|.:.|.|.|:|.:.|:.....|.. |.|.:|
Zfish    73 -----FTGNEKWSLDPRVVLLNTAVNEYSIKILNVNLYDEGPYVCSILTNKKPESTKVHLIVQVP 132

  Fly   211 PDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITW--RREDGREIIARNGSHQKTKAQSVEGEM 273
            ..|:|..|  |:.|.||.:..|:|.|.|.|:|.|.|  |...|..|:             .|||.
Zfish   133 ARIVNVST--DVSVNEGSNVSLMCLAIGRPEPSILWKFRSSKGNRIV-------------TEGEY 182

  Fly   274 LTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASP 338
            :.::.||:...|:|.||.||.:.|...:.:::.|::.|::..... .|..|.....|.|...|.|
Zfish   183 VEMTGITKDMSGSYDCITSNDISPPDVRTVQVTVNYPPVISRARS-TGTAVGQKGVLWCEASAVP 246

  Fly   339 KAINYWQRENGE-MIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTI 402
            .|...|.:  || .|:.|......|.:..    :.:|....:...|:|.|.|::.|::|.|..:|
Zfish   247 LADFQWFK--GERRILNGFNGVKIENKGK----QSMLTFFNVSEEDYGNYTCVAINTLGITNASI 305

  Fly   403 RLY 405
            .||
Zfish   306 ILY 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	30/127 (24%)
		ig	102..195	CDD:278476	25/110 (23%)
		IG_like	219..307	CDD:214653	27/89 (30%)
		Ig	221..307	CDD:299845	27/87 (31%)
		Ig	311..404	CDD:299845	23/93 (25%)
		IG_like	327..405	CDD:214653	20/78 (26%)
opcml	NP_001005580.1	Ig	41..129	CDD:299845	27/107 (25%)
		IG_like	41..129	CDD:214653	27/107 (25%)
		IG_like	139..216	CDD:214653	28/91 (31%)
		IGc2	146..202	CDD:197706	22/68 (32%)
		I-set	219..307	CDD:254352	23/94 (24%)
		ig	223..307	CDD:278476	22/90 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576290
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.800