DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and negr1

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	441	Identity:	106/441 - (24%)
Similarity:	169/441 - (38%)	Gaps:	122/441 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 RWQLLLLLLL----------GNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNN 123
            :|...::|.|          |..:|.|.|:                |:|...||..|...|.:.
Zfish    15 QWLTAIILSLCCFLPSCLPAGQTVDYTTSS----------------ESVVSRQGDTALLRCYLL- 62

  Fly   124 LGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHN--DYNTWTLNIRGVKMEDA 186
                    ||.|   |.||:  :..:|:.......:.:.|:|:..|  |.:.::|.|:.|.:.|.
Zfish    63 --------DGIS---KGAWL--NRSSIIYAGNDKWSGDPRVSIVSNVGDKHEYSLQIQKVDVTDE 114

  Fly   187 GKYMCQV----NTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWR 247
            |.|.|.:    |..|..:|   |.|.:||.|.  :.|.|:.|.||.:..|:|.|.|.|:|||:||
Zfish   115 GVYTCSIQSERNLHPKLIQ---LIVKVPPKIY--DISSDITVNEGSNVSLICAASGKPEPKISWR 174

  Fly   248 REDGREIIARNGSHQKTKAQSVE-GEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHP 311
                         |....|:..| ||.|.::.|:|.:.|.|.|.|.|.:....:|.:::.|:|.|
Zfish   175 -------------HISPSARKYESGEYLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPP 226

  Fly   312 LVQV-------PNQLVGAPVLTDVTLICNVEASPKAINYWQRENGE-MIIAGDRYALTEKENNMY 368
            .:..       |.|:        ..|.|...|.|..:..|.:  || .|..|....:    ||:
Zfish   227 AIHEMKSHGVRPGQV--------ALLRCEAAAVPSPVFEWYK--GEKRINMGQGIVI----NNL- 276

  Fly   369 AIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDT 433
            :...:|.:|.:....:|.|.|::.|.:|....::.|                     |.:::..|
Zfish   277 SSRSVLTVKNMTQDRYGNYTCVAVNRLGTANASVPL---------------------NPIIEPTT 320

  Fly   434 RSEDGSRNLNGRLYKDRAPDQHPASGSDQLLGRGTMRLIGTFLLALLVLFT 484
            .|...|...|..:|..       ..|::.||.      ....:|||..|.|
Zfish   321 TSAVSSPASNPAMYGS-------TGGAEVLLA------CWYLILALSSLVT 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	29/116 (25%)
		ig	102..195	CDD:278476	24/98 (24%)
		IG_like	219..307	CDD:214653	29/88 (33%)
		Ig	221..307	CDD:299845	28/86 (33%)
		Ig	311..404	CDD:299845	21/100 (21%)
		IG_like	327..405	CDD:214653	18/78 (23%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	25/108 (23%)
		IG_like	44..136	CDD:214653	28/124 (23%)
		I-set	140..222	CDD:254352	31/96 (32%)
		IGc2	153..208	CDD:197706	24/67 (36%)
		IG_like	236..312	CDD:214653	20/90 (22%)
		IGc2	238..304	CDD:197706	19/80 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576288
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.750