DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-beta and Lac

DIOPT Version :9

Sequence 1:NP_001138225.1 Gene:DIP-beta / 33125 FlyBaseID:FBgn0259245 Length:555 Species:Drosophila melanogaster
Sequence 2:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster


Alignment Length:349 Identity:87/349 - (24%)
Similarity:163/349 - (46%) Gaps:54/349 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 LGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCV----VNNLGGHRVSGDGSSAPA 138
            :.||:..|:...|         ||    ..|:|| |..|.:.:    :.::|| .|..|.|...|
  Fly     6 ISNCVWSTLLLAI---------FV----QQTLAQ-RTPTISYITQEQIKDIGG-TVEFDCSVQYA 55

  Fly   139 K---VAWIKADAKAI-LAIHEHVITNNDRLSVQHN-DYNTWTLNIRGVKMEDAGKYMCQVNTDPM 198
            |   |.::|.|:..: |:....::..:.|.|:::: :.:|:.|.|:.::..|||.|.|||....:
  Fly    56 KEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTV 120

  Fly   199 KMQTATLEV-VIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQ 262
            ...:|.::: |..|.:|::.::..::..||...::.|.|.|:|.|.||||||        |.:..
  Fly   121 HKVSAEVKLSVRRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRE--------NNAIL 177

  Fly   263 KTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTD 327
            .|.:.:..|..|.:..:.:.:.|.|.|:|.|||.....:.:.::|.|.|::.||...:|..:..|
  Fly   178 PTDSATYVGNTLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYD 242

  Fly   328 VTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAI----------EMILHIKRLQSS 382
            :.|.|::||.|.....|.:::.::           ..|..|:|          :..|.:..::..
  Fly   243 MDLECHIEAYPPPAIVWTKDDIQL-----------ANNQHYSISHFATADEYTDSTLRVITVEKR 296

  Fly   383 DFGGYKCISKNSIGDTEGTIRLYE 406
            .:|.|.|.:.|..|:.|..:.|:|
  Fly   297 QYGDYVCKATNRFGEAEARVNLFE 320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-betaNP_001138225.1 I-set 98..209 CDD:254352 31/120 (26%)
ig 102..195 CDD:278476 28/101 (28%)
IG_like 219..307 CDD:214653 24/87 (28%)
Ig 221..307 CDD:299845 24/85 (28%)
Ig 311..404 CDD:299845 21/102 (21%)
IG_like 327..405 CDD:214653 17/87 (20%)
LacNP_523713.2 IG_like 36..131 CDD:214653 24/95 (25%)
FR1 37..50 CDD:409353 3/13 (23%)
Ig strand A' 37..42 CDD:409353 0/4 (0%)
Ig strand B 44..51 CDD:409353 3/7 (43%)
CDR1 51..59 CDD:409353 3/7 (43%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 1/13 (8%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 0/1 (0%)
FR3 84..115 CDD:409353 10/30 (33%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 0/7 (0%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 23/81 (28%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 1/3 (33%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 20/101 (20%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 1/3 (33%)
Ig strand F 300..305 CDD:409353 2/4 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45442805
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265311at33208
OrthoFinder 1 1.000 - - FOG0000150
OrthoInspector 1 1.000 - - otm40772
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR12231
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
87.850

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