DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and itgb4

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	455	Identity:	88/455 - (19%)
Similarity:	153/455 - (33%)	Gaps:	159/455 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDG--------------SSAPAKVAWIKAD 146
            |..:.:.|..|..|  |:..|...:|.:  |.   |||              :::|....:..|:
Zfish  1187 FNLELLDPSNNAII--GKRKTTEVIVTD--GR---GDGKNQDFQKMEYVTQTATSPGGRLYSPAN 1244

  Fly   147 AKAILAIHEHVITNNDRLSVQHNDYNTW--TLNIRGVKM--------EDAGKYMCQVNTDPMKMQ 201
            .||:....:::..|             |  :.|..|.|:        ||..|:|      .:|..
Zfish  1245 IKAVATGPKNIRLN-------------WKPSQNANGYKVKYWIYGDPEDKAKFM------DVKTP 1290

  Fly   202 TATLEVVIP-------------------PDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWR 247
            .|.|..:.|                   .|||..:|..|  :| |...:|..........:::|.
Zfish  1291 QAELTNLDPYCDYEMRVCGYNALGDGNYSDIIQCQTLED--IP-GEPGRLAFNVISPTVTQVSWA 1352

  Fly   248 RE-------DGREII--------ARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGV-- 295
            ..       .|.|:|        ...|..:|....:.:..||.:..:..|:...|...|||.|
Zfish  1353 EPAEANGIITGYEVIYMPINEDKKPTGPPKKVMIDNPKKRMLLIENLQPSQTYCYKVRASNKVGW 1417

  Fly   296 ----PPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMI---I 353
                ..|::           |...|.:.:..|::.|:.:: :.||..:..:|....| |::   .
Zfish  1418 GPYREATIN-----------LASQPTRPMSIPIIPDIPIV-DAEAGEEYDSYLMYSN-EVLRSPT 1469

  Fly   354 AGDRYALTEKENNMYAIEMILHIKRLQSSDF--GGYKCISKNSIGDTEGTIRLYEMERPGKKI-- 414
            :..|.::|:..::.:     ::.|..|:..|  ||...:|:| |..:..|   |....|...:
Zfish  1470 SSLRPSVTDLSDDQF-----VNGKWEQNFLFPGGGGGSLSRN-ISSSSTT---YSHSTPRTNVTN 1525

  Fly   415 --------------------LRDDDLNEVSKNEVVQKDTRSE-------DGSR------NLNGRL 446
                                :||..|   .|.:|:.: .|||       ||.|      ||:|.|
Zfish  1526 NSSTTTYISGKGGSTTHRYDVRDGGL---LKEDVILR-KRSENRHYTEGDGVRDSIVMGNLSGGL 1586

Fly 447 446
Zfish 1587 1586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	26/134 (19%)
		ig	102..195	CDD:278476	23/116 (20%)
		IG_like	219..307	CDD:214653	19/108 (18%)
		Ig	221..307	CDD:299845	19/106 (18%)
		Ig	311..404	CDD:299845	20/97 (21%)
		IG_like	327..405	CDD:214653	17/82 (21%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020	19/102 (19%)
		FN3	1331..1420	CDD:238020	17/89 (19%)
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900