Protein Alignment DIP-beta and MDGA1

DIOPT Version :10

• Sequence 1: NP_001138225.1
• Gene: DIP-beta / 33125
• FlyBaseID: FBgn0259245
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: XP_006715119.1
• Gene: MDGA1 / 266727
• HGNCID: 19267
• Length: 973
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 112/465 - (24%)
• Similarity: 185/465 - (39%)
• Gaps: 93/465 - (20%)

  Fly    40 LAQLEIASGSGLVGLGTGTGTGSGCGPAIR------WQLLLLLLLGNCIDLTVSNKISSV--GAF 96
            |.||:.:.|.|.:.||.....|:...|:::      :.......:||....||:..:.|:  ..|
Human   270 LPQLQWSHGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATF 334

  Fly    97 E--PDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVIT 159
            :  ||.:...||:.:  |:|...:|.|:.:...:|:         ..|.|....|.:
Human   335 QITPDVIKESENIQL--GQDLKLSCHVDAVPQEKVT---------YQWFKNGKPARM-------- 380

  Fly   160 NNDRLSVQHNDYN----TWTLNIRGVKMEDAGKYMCQVNTDPMKMQTATLEV-----VIPPDIIN 215
             :.||.|..||..    |.:|.:..:...|.|.|:|..:.....:...::||     .:||.|..
Human   381 -SKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISV 444

  Fly   216 EETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKIT 280
            .:....:.|.||..|:|.|..||.|:|.:.|.|.|....:..:|...:   ::.:|: |.|.:::
Human   445 PKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLE---ETPDGK-LRLERVS 505

  Fly   281 RSEMGAYMCIAS--NG--VPPTVSKRMKLQVHFHPLV----QVPNQLVGAPVLTDVTLICNVEAS 337
            |...|.|.|..:  ||  |.|. ..:::|.|.|.|.|    |...|.:|.|||...:|:   ..|
Human   506 RDMSGTYRCQTARYNGFNVRPR-EAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLL---RGS 566

  Fly   338 PKAI--NYWQRENGEM-----IIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSI 395
            |:.|  ..| |..|::     ::.....|....|         |.:..:.....|.|:|...|.:
Human   567 PQRIASAVW-RFKGQLLPPPPVVPAAAEAPDHAE---------LRLDAVTRDSSGSYECSVSNDV 621

  Fly   396 GDT----EGTIRLYEME------RPGKKILRDDDLNEVSKN--EVVQKDTRSEDG-SRNLNGRLY 447
            |..    :.:.:.|..|      .|.:.       :::|||  .|:|...|..|. ...||.||
Human   622 GSAACLFQVSAKAYSPEFYFDTPNPTRS-------HKLSKNYSYVLQWTQREPDAVDPVLNYRL- 678

  Fly   448 KDRAPDQHPA 457
            ..|..:||.|
Human   679 SIRQLNQHNA 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	Ig	98..209	CDD:472250	25/119 (21%)
		Ig strand B	115..119	CDD:409353	0/3 (0%)
		Ig strand C	139..143	CDD:409353	0/3 (0%)
		Ig strand E	174..178	CDD:409353	1/3 (33%)
		Ig strand F	188..193	CDD:409353	2/4 (50%)
		Ig strand G	202..205	CDD:409353	0/2 (0%)
		Ig	211..307	CDD:472250	28/99 (28%)
		Ig strand B	230..234	CDD:409353	2/3 (67%)
		Ig strand C	243..247	CDD:409353	0/3 (0%)
		Ig strand E	272..276	CDD:409353	1/3 (33%)
		Ig strand F	286..291	CDD:409353	2/4 (50%)
		Ig strand G	300..303	CDD:409353	0/2 (0%)
		IG_like	327..405	CDD:214653	15/88 (17%)
		Ig strand B	328..332	CDD:409353	1/3 (33%)
		Ig strand C	341..346	CDD:409353	2/6 (33%)
		Ig strand E	365..376	CDD:409353	1/10 (10%)
		Ig strand F	386..391	CDD:409353	2/4 (50%)
		Ig strand G	399..402	CDD:409353	0/2 (0%)
MDGA1	XP_006715119.1	Ig	44..115	CDD:472250
		Ig strand B	56..60	CDD:409353
		Ig strand C	69..73	CDD:409353
		Ig strand E	91..95	CDD:409353
		Ig strand F	105..110	CDD:409353
		IG_like	152..217	CDD:214653
		Ig strand B	153..157	CDD:409353
		Ig strand C	166..170	CDD:409353
		Ig strand E	197..201	CDD:409353
		Ig strand F	211..216	CDD:409353
		IG_like	248..326	CDD:214653	13/55 (24%)
		Ig strand B	258..262	CDD:409412
		Ig strand C	272..276	CDD:409412	2/3 (67%)
		Ig strand E	291..295	CDD:409412	1/3 (33%)
		Ig strand F	305..310	CDD:409412	0/4 (0%)
		Ig	334..418	CDD:472250	24/103 (23%)
		Ig strand B	353..357	CDD:409353	0/3 (0%)
		Ig strand C	368..372	CDD:409353	0/12 (0%)
		Ig strand E	398..402	CDD:409353	1/3 (33%)
		Ig strand F	412..417	CDD:409353	2/4 (50%)
		Ig_3	439..515	CDD:464046	23/79 (29%)
		Ig_3	538..619	CDD:464046	21/93 (23%)
		MAM	753..916	CDD:99706