DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and NEGR1

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	358	Identity:	93/358 - (25%)
Similarity:	150/358 - (41%)	Gaps:	68/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GSGCGPAIRWQLLLLL----LLGNCIDLTVSNKISSVGAFEPDFV-IPLENVTIAQGRDATFTCV 120
            |:.|  :.:|...:||    ||.:|:....|          .||. ..::|:.:.:|..|...|.
Human     9 GACC--SNQWLAAVLLSLCCLLPSCLPAGQS----------VDFPWAAVDNMMVRKGDTAVLRCY 61

  Fly   121 VNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMED 185
            :.         ||:|   |.||:  :..:|:.......:.:.|:|:...:...::|.|:.|.:.|
Human    62 LE---------DGAS---KGAWL--NRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTD 112

  Fly   186 AGKYMCQVNTD--PMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRR 248
            .|.|.|.|.|.  |..|| ..|.|.:||.|.  :.|.||.|.||.:..|.|.|.|.|:|.|:||
Human   113 DGPYTCSVQTQHTPRTMQ-VHLTVQVPPKIY--DISNDMTVNEGTNVTLTCLATGKPEPSISWR- 173

  Fly   249 EDGREIIARNGSHQKTKAQSVE-GEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPL 312
                        |....|:..| |:.|.:..|||.:.|.|.|.|.|.|.....:::|:.|:|.|.
Human   174 ------------HISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPT 226

  Fly   313 VQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRE----NGE--MIIAGDRYALTEKENNMYAIE 371
            :|........|..:.:.........|.|..:::.|    ||:  :||..            ::..
Human   227 IQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQN------------FSTR 279

  Fly   372 MILHIKRLQSSDFGGYKCISKNSIGDTEGTIRL 404
            .||.:..:....||.|.|::.|.:|.|..::.|
Human   280 SILTVTNVTQEHFGNYTCVAANKLGTTNASLPL 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	29/113 (26%)
		ig	102..195	CDD:278476	21/92 (23%)
		IG_like	219..307	CDD:214653	30/88 (34%)
		Ig	221..307	CDD:299845	29/86 (34%)
		Ig	311..404	CDD:299845	19/98 (19%)
		IG_like	327..405	CDD:214653	17/84 (20%)
NEGR1	NP_776169.2	IG	47..135	CDD:214652	26/102 (25%)
		IGc2	152..210	CDD:197706	24/70 (34%)
		Ig_3	225..301	CDD:372822	16/87 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143403
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750