DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and rig-5

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001251131.1	Gene:	rig-5 / 172791	WormBaseID:	WBGene00004372	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	428	Identity:	138/428 - (32%)
Similarity:	211/428 - (49%)	Gaps:	60/428 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 ASGSGLVGLGTGTGTGSGCGPAIRWQLL----------LLLLLGNCIDLTVSNKISSVGAFEPDF 100
            |..|.|.|..|..|.|       |:.:|          |..||  |..|.|..:..|.|| .|..
Worm    32 ARDSALSGAPTFRGRG-------RFVILFHIPLQEKMYLFALL--CGVLLVFKQACSRGA-PPTI 86

  Fly   101 VIPLENVTIA-QGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADA-KAILAIHEHVITNNDR 163
            ..|..:..:| .|:|..|||:||:||.|           .||::|||: ..:|:..|.|....::
Worm    87 QQPSMSSAVALLGQDVDFTCIVNDLGSH-----------MVAFVKADSPPRLLSFDEKVFRRRNK 140

  Fly   164 LSVQ------HNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGDM 222
            ..::      ||:   |.|.|:.|:..|.|.|.||:||:|:.:.|..|:|.:|| :::..|...:
Worm   141 YELKPRIGDLHNE---WVLTIKNVQESDRGNYSCQINTEPITLSTGELDVKVPP-VVSRSTPAAV 201

  Fly   223 MVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAY 287
            .|.||.:..|.|:|.|:|.|.:.|||:| |:||..||: ....|....|.:|.|:|::|..|..|
Worm   202 EVREGNNVSLTCKADGNPTPTVIWRRQD-RQIIRYNGA-TGFGASVFHGPVLHLTKVSRKHMSEY 264

  Fly   288 MCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMI 352
            :|:||||:||..|..:||.|.|.||||..::.|.|.|.:...::|..||.|:....|::: ||.:
Worm   265 LCVASNGIPPDESWTVKLLVTFPPLVQAQSETVQASVGSMARMVCTTEAWPRPEMGWEKD-GEPV 328

  Fly   353 IAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMER-------- 409
            ...:..|:|...:..|....||.|:.:|||.||.|:|::||..|.....:.|.::..
Worm   329 YESNNVAMTHTVSGQYHSVHILEIRNVQSSHFGVYRCVAKNDNGIHHSQVTLNQISHNHFTNSNL 393

  Fly   410 --PGKKILR----DDDLNEVSKNEVVQKDTRSEDGSRN 441
              .|..:.|    ||:.:|...|...||:...|:.|::
Worm   394 IPEGSGMPRGYSEDDEADEEEDNLENQKNDSEEEDSQS 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	38/118 (32%)
		ig	102..195	CDD:278476	31/100 (31%)
		IG_like	219..307	CDD:214653	36/87 (41%)
		Ig	221..307	CDD:299845	36/85 (42%)
		Ig	311..404	CDD:299845	30/92 (33%)
		IG_like	327..405	CDD:214653	23/77 (30%)
rig-5	NP_001251131.1	IG_like	92..189	CDD:214653	36/110 (33%)
		Ig_3	191..270	CDD:372822	30/81 (37%)
		IG	294..380	CDD:214652	26/86 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165770
Domainoid	1	1.000	77	1.000	Domainoid score	I5731
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I2513
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm14489
orthoMCL	1	0.900	-	-		OOG6_122504
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16937
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930