DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-beta and BTNL9

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_024310148.1	Gene:	BTNL9 / 153579	HGNCID:	24176	Length:	564	Species:	Homo sapiens

Alignment Length:	486	Identity:	91/486 - (18%)
Similarity:	168/486 - (34%)	Gaps:	127/486 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTC-VVNNLGGHRVSGDGSSAPA 138
            |:.|.:.:.|......|.|....|::.|     ....|.:..|.| :...|...::
Human    20 LVFLMHLLLLQPGEPSSEVKVLGPEYPI-----LALVGEEVEFPCHLWPQLDAQQM--------- 70

  Fly   139 KVAWIKADAKAILAIHEH----------VITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQV 193
            ::.|.::....::.:::.          ...|..:|......|.:..|.:..:...|.|.|.|:.
Human    71 EIRWFRSQTFNVVHLYQEQQELPGRQMPAFRNRTKLVKDDIAYGSVVLQLHSIIPSDKGTYGCRF 135

  Fly   194 NTDPMKMQTATLEVVIPPDIINEETSGDMMVP----EG---GSAKLVCRARG-HPKPKITWRRED 250
            ::|....: |..|:         |.:|....|    ||   |..:|..|:.| :||||:.||...
Human   136 HSDNFSGE-ALWEL---------EVAGLGSDPHLSLEGFKEGGIQLRLRSSGWYPKPKVQWRDHQ 190

  Fly   251 GR------EIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHF 309
            |:      |.|..:.....:...||......||.::.|.....:           |::.:|
Human   191 GQCLPPEFEAIVWDAQDLFSLETSVVVRAGALSNVSVSIQNLLL-----------SQKKEL---- 240

  Fly   310 HPLVQVPNQLV-GAPV-----LTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMY 368
              :||:.:..| ||..     :..:.|:..:.|....:...||.:.|.:    |....:::..:.
Human   241 --VVQIADVFVPGASAWKSAFVATLPLLLVLAALALGVLRKQRRSREKL----RKQAEKRQEKLT 299

  Fly   369 AIEMILHIKRLQSS-DF----------GGYKCISKNSIGDTEGTIRLYEMERPGKKILR-----D 417
            |     .:::||:. |:          ...|...|..:....|. .....:|||:.:..     |
Human   300 A-----ELEKLQTELDWRRAEGQAEWRAAQKYAEKREVCPPWGR-HGRGPDRPGRALTLWLCAVD 358

  Fly   418 DDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKDRAPDQHPASGSDQL------------------L 464
            ..|:..|.:..::.   |||| ::::.|.........||...|:|.                  :
Human   359 VTLDPASAHPSLEV---SEDG-KSVSSRGAPPGPAPGHPQRFSEQTCALSLERFSAGRHYWEVHV 419

  Fly   465 GRGTMRLIGTFLLALLVLFTALAEAGPTTLS 495
            ||.:...:|..|       .|:..|||..||
Human   420 GRRSRWFLGACL-------AAVPRAGPARLS 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	18/121 (15%)
		ig	102..195	CDD:278476	14/103 (14%)
		IG_like	219..307	CDD:214653	24/101 (24%)
		Ig	221..307	CDD:299845	23/99 (23%)
		Ig	311..404	CDD:299845	18/109 (17%)
		IG_like	327..405	CDD:214653	13/88 (15%)
BTNL9	XP_024310148.1	Ig_MOG_like	52..151	CDD:319291	17/117 (15%)
		bZIP	<281..317	CDD:328730	7/44 (16%)
		SPRY_PRY_C-I_1	358..532	CDD:293968	22/97 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000