DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-beta and IGSF5

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_011527774.1	Gene:	IGSF5 / 150084	HGNCID:	5952	Length:	497	Species:	Homo sapiens

Alignment Length:	359	Identity:	72/359 - (20%)
Similarity:	116/359 - (32%)	Gaps:	120/359 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SCSQEHTTKFS-------PKLSQVAKHRKLAQLEIA-------------SGSG-----LVGLGTG 57
            ||....|:.||       ..:..:..||.|.|...|             :|..     |:.|...
Human    58 SCPLSLTSNFSRDGVCFCSVVKSLHAHRGLLQARAARFYFLHQDSSHATNGESSQLLELIFLEKN 122

  Fly    58 TGTGSGC----GPAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFT 118
            .|:|||.    ||                                      :|..:.:|..|.|.
Human   123 AGSGSGNEVIEGP--------------------------------------QNARVLKGSQARFN 149

  Fly   119 CVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIH--EHVITNNDRLSVQHNDYN---TWTLNI 178
            |.|:.  |.::          :.|..:| ..:|::.  |.:|| |||.:.|..|..   |..:.|
Human   150 CTVSQ--GWKL----------IMWALSD-MVVLSVRPMEPIIT-NDRFTSQRYDQGGNFTSEMII 200

  Fly   179 RGVKMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLV------CRAR 237
            ..|:..|:|...|.:....:. .:|.|.|         :..|::.:|   |..||      |...
Human   201 HNVEPSDSGNIRCSLQNSRLH-GSAYLTV---------QVMGELFIP---SVNLVVAENEPCEVT 252

  Fly   238 GHPK-----PKITWRREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIAS-NGVP 296
            ..|.     |.|:|  |.|  ::..:.|:......|.....:::..:|....|...|:|: ..:.
Human   253 CLPSHWTRLPDISW--ELG--LLVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLK 313

  Fly   297 PTVSKRMKLQVHFHPL-----VQVPNQLVGAPVL 325
            ...|..:.|.|...|.     :.:|..|...|.|
Human   314 ARKSATVNLTVIRCPQDTGGGINIPGVLSSLPSL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	27/115 (23%)
		ig	102..195	CDD:278476	24/97 (25%)
		IG_like	219..307	CDD:214653	20/99 (20%)
		Ig	221..307	CDD:299845	19/97 (20%)
		Ig	311..404	CDD:299845	5/20 (25%)
		IG_like	327..405	CDD:214653
IGSF5	XP_011527774.1	IG_like	135..228	CDD:214653	27/145 (19%)
		Ig	<200..230	CDD:299845	8/39 (21%)
		Ig	236..307	CDD:299845	16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840