DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and Dscam

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_006522949.1	Gene:	Dscam / 13508	MGIID:	1196281	Length:	2034	Species:	Mus musculus

Alignment Length:	400	Identity:	101/400 - (25%)
Similarity:	150/400 - (37%)	Gaps:	80/400 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNND 162
            |.|:.|.|....:.|:.....|||       ||||   .|..:.|.| |.:.|.|.....|.|.|
Mouse   596 PPFIQPFEFPRFSIGQRVFIPCVV-------VSGD---LPITITWQK-DGRPIPASLGVTIDNID 649

  Fly   163 RLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQ-TATLEVVIPPDIINEETSGDMMVPE 226
            ..|         :|.|..:.:...|.|.|....:...:: .:.|.|.:||..:.:....|.:.
Mouse   650 FTS---------SLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY-- 703

  Fly   227 GGSAKLVCRARGHPKPKITWRREDGREI-----IARNGSHQKTKAQSVEGEMLTLSKITRSEMGA 286
            |.:..|.|.|.|:|.|.|.|:...|..:     ||.||     :.|.:....|.:..:...:.|.
Mouse   704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNG-----RIQVLSNGSLLIKHVVEEDSGY 763

  Fly   287 YMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVT------LICNVEASPKAINYWQ 345
            |:|..||.|...|||.|.|      .|::|..:...|..|..|      :.|........|..|:
Mouse   764 YLCKVSNDVGADVSKSMYL------TVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWE 822

  Fly   346 RE----NGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYE 406
            :|    |.||.    ||.::.||.....|. .|.|......|.|.:.|.:.||.|:..|.|:|..
Mouse   823 KEDRIINPEMA----RYLVSTKEVGEEVIS-TLQILPTVREDSGFFSCHAINSYGEDRGIIQLTV 882

  Fly   407 MERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRNLNG---------------RLYKDRAP---- 452
            .|.|...   :.::.:|....:..:.|...||:..:.|               :..||.:|
Mouse   883 QEPPDPP---EIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNS 944

  Fly   453 ----DQHPAS 458
                |.||:|
Mouse   945 ATIIDIHPSS 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	29/111 (26%)
		ig	102..195	CDD:278476	25/92 (27%)
		IG_like	219..307	CDD:214653	28/92 (30%)
		Ig	221..307	CDD:299845	28/90 (31%)
		Ig	311..404	CDD:299845	27/102 (26%)
		IG_like	327..405	CDD:214653	23/87 (26%)
Dscam	XP_006522949.1	Ig	15..115	CDD:386229
		IGc2	239..300	CDD:197706
		IG	320..400	CDD:214652
		Ig_3	410..488	CDD:372822
		IGc2	518..575	CDD:197706
		Ig	596..686	CDD:386229	28/109 (26%)
		Ig_DSCAM	707..784	CDD:143211	26/87 (30%)
		Ig	802..889	CDD:386229	25/91 (27%)
		FN3	885..978	CDD:238020	12/72 (17%)
		FN3	986..1083	CDD:238020
		FN3	1091..1184	CDD:238020
		FN3	1189..1278	CDD:238020
		Ig_3	1301..1363	CDD:372822
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810