DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-beta and BTN3A2

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_006715042.1	Gene:	BTN3A2 / 11118	HGNCID:	1139	Length:	339	Species:	Homo sapiens

Alignment Length:	393	Identity:	82/393 - (20%)
Similarity:	131/393 - (33%)	Gaps:	95/393 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSA 136
            |||:.||..|     |.:.|.:|...|        :....|.||...|        .:....|:.
Human    18 LLLVQLLTPC-----SAQFSVLGPSGP--------ILAMVGEDADLPC--------HLFPTMSAE 61

  Fly   137 PAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNT----------WTLNIRGVKMEDAGKYMC 191
            ..::.|:.:..:.::.::.......||.|..:....:          ..|.|..|...|:|||:|
Human    62 TMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLC 126

  Fly   192 QV-NTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARG-HPKPKITWRREDGREI 254
            .. :.|..:.....|:|......::.|..|    .|.|...|.||:.| :|:|:|.|....|..|
Human   127 YFQDGDFYEKALVELKVAALGSNLHVEVKG----YEDGGIHLECRSTGWYPQPQIQWSNAKGENI 187

  Fly   255 IARNGSHQKTKAQSVEGEMLTLSKITRSEMG-AYMCIASN---GVPPTVSKRMKLQVHFHPLVQV 315
            .|   ......|..|....:..|.|.|...| ...||..|   |:..|.|..:.......|..:.
Human   188 PA---VEAPVVADGVGLYEVAASVIMRGGSGEGVSCIIRNSLLGLEKTASISIAALPFADPFFRS 249

  Fly   316 PNQLVGA-----PVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILH 375
            ....:.|     |:|.                        :::||..|.|..::..:.|:
Human   250 AQPWIAALAGTLPILL------------------------LLLAGASYFLWRQQKEITAL----- 285

  Fly   376 IKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSR 440
                 ||:....:.:.:.....||..|.|.|            .|.|..|.:.:|..||.|:.|.
Human   286 -----SSEIESEQEMKEMGYAATEREISLRE------------SLQEELKRKKIQYLTRGEESSS 333

  Fly   441 NLN 443
            :.|
Human   334 DTN 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	21/121 (17%)
		ig	102..195	CDD:278476	17/103 (17%)
		IG_like	219..307	CDD:214653	26/92 (28%)
		Ig	221..307	CDD:299845	25/90 (28%)
		Ig	311..404	CDD:299845	14/97 (14%)
		IG_like	327..405	CDD:214653	10/77 (13%)
BTN3A2	XP_006715042.1	IG_like	37..143	CDD:214653	20/121 (17%)
		Ig_MOG_like	45..144	CDD:143190	19/106 (18%)
		MYO10_CC	277..330	CDD:293340	14/74 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910