Protein Alignment DIP-beta and CHL1

DIOPT Version :10

• Sequence 1: NP_001138225.1
• Gene: DIP-beta / 33125
• FlyBaseID: FBgn0259245
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_006605.2
• Gene: CHL1 / 10752
• HGNCID: 1939
• Length: 1224
• Species: Homo sapiens
• Alignment Length: 378
• Identity: 86/378 - (22%)
• Similarity: 129/378 - (34%)
• Gaps: 104/378 - (27%)

  Fly    86 VSNKISSVGAFEPDFVIP------LENVTIAQGRDATFTCVV----------NNLGGHRVSGDGS 134
            :.:|.:|:...:|..::|      ..::||.:|......|..          |.:||....|..:
Human   239 IGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLPTPQVDWNKIGGDLPKGRET 303

  Fly   135 SAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMK 199
            .                                 .:|.. ||.|..|..:|.|.|.|   |....
Human   304 K---------------------------------ENYGK-TLKIENVSYQDKGNYRC---TASNF 331

  Fly   200 MQTAT--LEVVI--PPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGS 260
            :.|||  ..|::  ||....:..|.  :...|.:..|:|.|.|.|:|.|.||         .|||
Human   332 LGTATHDFHVIVEEPPRWTKKPQSA--VYSTGSNGILLCEAEGEPQPTIKWR---------VNGS 385

  Fly   261 ---HQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQ-VHFHPLVQVPN---- 317
               :.......|....::.:.:..:....|.|.||| |..|:.....:. |...||:|..:
Human   386 PVDNHPFAGDVVFPREISFTNLQPNHTAVYQCEASN-VHGTILANANIDVVDVRPLIQTKDGENY 449

  Fly   318 -QLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQS 381
             .:||....    |.|...|||:|:..||:......:.|.||.:.|...        |.|.|...
Human   450 ATVVGYSAF----LHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGT--------LQINRTTE 502

  Fly   382 SDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTR 434
            .|.|.|.|..:|:||.|..|..|              |:...:|..|..|:.|
Human   503 EDAGSYSCWVENAIGKTAVTANL--------------DIRNATKLRVSPKNPR 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	Ig	98..209	CDD:472250	24/128 (19%)
		Ig strand B	115..119	CDD:409353	0/3 (0%)
		Ig strand C	139..143	CDD:409353	0/3 (0%)
		Ig strand E	174..178	CDD:409353	2/3 (67%)
		Ig strand F	188..193	CDD:409353	2/4 (50%)
		Ig strand G	202..205	CDD:409353	3/4 (75%)
		Ig	211..307	CDD:472250	23/99 (23%)
		Ig strand B	230..234	CDD:409353	1/3 (33%)
		Ig strand C	243..247	CDD:409353	1/3 (33%)
		Ig strand E	272..276	CDD:409353	0/3 (0%)
		Ig strand F	286..291	CDD:409353	2/4 (50%)
		Ig strand G	300..303	CDD:409353	0/2 (0%)
		IG_like	327..405	CDD:214653	24/77 (31%)
		Ig strand B	328..332	CDD:409353	1/3 (33%)
		Ig strand C	341..346	CDD:409353	1/4 (25%)
		Ig strand E	365..376	CDD:409353	1/10 (10%)
		Ig strand F	386..391	CDD:409353	2/4 (50%)
		Ig strand G	399..402	CDD:409353	0/2 (0%)
CHL1	NP_006605.2	Ig	35..126	CDD:472250
		Ig strand B	53..57	CDD:409396
		Ig strand C	66..70	CDD:409396
		Ig strand E	90..94	CDD:409396
		Ig strand F	106..111	CDD:409396
		Ig strand G	120..123	CDD:409396
		IgI_2_L1-CAM_like	135..225	CDD:409432
		Ig strand A	135..138	CDD:409432
		Ig strand A'	140..144	CDD:409432
		Ig strand B	147..155	CDD:409432
		Ig strand C	162..168	CDD:409432
		Ig strand C'	171..174	CDD:409432
		Ig strand D	180..184	CDD:409432
		Ig strand E	186..190	CDD:409432
		Ig strand F	201..209	CDD:409432
		Ig strand G	212..225	CDD:409432
		Ig3_L1-CAM_like	262..344	CDD:409394	22/118 (19%)
		Ig strand B	274..278	CDD:409394	0/3 (0%)
		Ig strand C	287..291	CDD:409394	0/3 (0%)
		Ig strand E	309..313	CDD:409394	2/4 (50%)
		Ig strand F	323..328	CDD:409394	2/7 (29%)
		Ig strand G	336..339	CDD:409394	1/2 (50%)
		Ig4_L1-NrCAM_like	348..435	CDD:409367	22/98 (22%)
		Ig strand B	364..368	CDD:409367	1/3 (33%)
		Ig strand C	377..381	CDD:409367	1/3 (33%)
		Ig strand E	400..404	CDD:409367	0/3 (0%)
		Ig strand F	414..419	CDD:409367	2/4 (50%)
		Ig strand G	427..430	CDD:409367	0/2 (0%)
		Ig	448..525	CDD:472250	26/88 (30%)
		Ig strand B	457..461	CDD:409390	1/7 (14%)
		Ig strand C	470..474	CDD:409390	0/3 (0%)
		Ig strand E	493..497	CDD:409390	1/11 (9%)
		Ig strand F	507..512	CDD:409390	2/4 (50%)
		Ig strand G	520..523	CDD:409390	0/2 (0%)
		Ig	548..617	CDD:409353
		Ig strand B	548..552	CDD:409353
		Ig strand C	565..569	CDD:409353
		DGEA	571..574
		Ig strand E	590..594	CDD:409353
		Ig strand F	604..609	CDD:409353
		FN3	<616..>868	CDD:442628
		FN3	628..717	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..732
		FN3	834..927	CDD:238020
		FN3	932..1027	CDD:238020
		Bravo_FIGEY	1120..1205	CDD:464016
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1179
		FIG[AQ]Y	1197..1201
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1205..1224