DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and Cd276

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_598744.1	Gene:	Cd276 / 102657	MGIID:	2183926	Length:	316	Species:	Mus musculus

Alignment Length:	398	Identity:	83/398 - (20%)
Similarity:	139/398 - (34%)	Gaps:	122/398 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GSGCGPAIRWQL-LLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNL 124
            |...|..:|..| :|.|.|...:::.||.          |.|:.|.:.      |||..|..:..
Mouse     7 GPSVGVCVRTALGVLCLCLTGAVEVQVSE----------DPVVALVDT------DATLRCSFSPE 55

  Fly   125 GGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITN--------NDR------LSVQHNDYNTWT 175
            .|.      |.|...:.|...|.|.::    |..|.        ::|      |.||.|.    :
Mouse    56 PGF------SLAQLNLIWQLTDTKQLV----HSFTEGRDQGSAYSNRTALFPDLLVQGNA----S 106

  Fly   176 LNIRGVKMEDAGKYMCQVNTDPMKMQTATLEVVIP---PDIINEETSGDMMVPEGGSAKLVCRA- 236
            |.::.|::.|.|.|.|.|:.........:|:|..|   |.:..|....   :..|....:.|.:
Mouse   107 LRLQRVRVTDEGSYTCFVSIQDFDSAAVSLQVAAPYSKPSMTLEPNKD---LRPGNMVTITCSSY 168

  Fly   237 RGHPKPKITWRREDGREI-IARNGSHQKTKAQSVEGEMLTLSKITRSEMGA---YMCIASNGVPP 297
            :|:|:.::.|:  ||:.: :..|.:   |...:.|..:..:..:.|..:||   |.|:..|.|
Mouse   169 QGYPEAEVFWK--DGQGVPLTGNVT---TSQMANERGLFDVHSVLRVVLGANGTYSCLVRNPV-- 226

  Fly   298 TVSKRMKLQVHFH--------PLVQVPNQL---VGAPVLTDVTLICNVEASPKAINYWQRENGEM 351
                   ||...|        ||...|..|   ||..|...|.|:.      .|...|::
Mouse   227 -------LQQDAHGSVTITGQPLTFPPEALWVTVGLSVCLVVLLVA------LAFVCWRK----- 273

  Fly   352 IIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILR 416
                                    ||:....:..|    :::..||.||:.......:|.:.  :
Mouse   274 ------------------------IKQSCEEENAG----AEDQDGDGEGSKTALRPLKPSEN--K 308

  Fly   417 DDDLNEVS 424
            :||..|::
Mouse   309 EDDGQEIA 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	29/124 (23%)
		ig	102..195	CDD:278476	25/106 (24%)
		IG_like	219..307	CDD:214653	18/92 (20%)
		Ig	221..307	CDD:299845	18/90 (20%)
		Ig	311..404	CDD:299845	18/95 (19%)
		IG_like	327..405	CDD:214653	11/77 (14%)
Cd276	NP_598744.1	IG_like	37..138	CDD:214653	27/120 (23%)
		Ig	44..139	CDD:299845	25/114 (22%)
		IgC	149..235	CDD:143166	21/102 (21%)
		IG_like	156..238	CDD:214653	20/95 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..316		9/41 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000