DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and ncam2

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_012811963.1	Gene:	ncam2 / 100151722	XenbaseID:	XB-GENE-1217730	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	110/474 - (23%)
Similarity:	177/474 - (37%)	Gaps:	84/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 TGTGS------GCGPAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDAT 116
            ||||.      ...|::....|.|||:.......:...:.|.|.......|.|..|.|:.|:...
Frog     4 TGTGGKLTYTLAQSPSLGTLSLHLLLIMKVSYFYLLGLLVSSGQALMQVTISLSKVEISVGQSKY 68

  Fly   117 FTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGV 181
            |||.        |.|:..:    :.|.....:.|:        :..|:.||.....:| |.|...
Frog    69 FTCT--------VIGEADN----IDWFNPQGEKII--------SGQRVVVQREGIRSW-LTIYKA 112

  Fly   182 KMEDAGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITW 246
            .::|||.|.||........|.||:.:.|...:..|:.........|.:|:::|.....|.|.:.|
Frog   113 NVDDAGIYRCQATDSKGHAQEATVVLEIYQKLTFEDVPSPQEFKRGENAEVLCLVSSSPAPMVRW 177

  Fly   247 --RREDGREIIARNGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHF 309
              .|||..:|..|       :...:....|.:..|::.:.|.|.|.....|...:..|     ..
Frog   178 LNNREDVTDIDDR-------RFAMLPNNNLQIKNISKRDEGIYRCEGRVEVRGEIDFR-----DI 230

  Fly   310 HPLVQVPNQLVG--------APVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENN 366
            ..:|.||.:::.        |..|.|:||.|....|||....|.| ||:::...::|.|.|....
Frog   231 SVIVNVPPEILAQQRSFNATADRLEDITLFCRATGSPKPYITWHR-NGKLVEENEKYDLREDNTE 294

  Fly   367 MYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNE--------V 423
                   |.:|.:.|:|.|.|.|.:.|..|.||....|....:|....|:::...|        .
Frog   295 -------LTVKNIISTDSGLYVCRATNKAGFTEKQSFLQVFVQPHIVQLQNETTIEHGHVTLTCE 352

  Fly   424 SKNEVVQKDT--RSEDGSRNLNGRLYKDRAPDQHPASGSDQLLGRGTMRLIGTFLLALLVLFTAL 486
            ::.|.:.:.|  ||.||....:|    |::.|....|....  |:.::.:....          |
Frog   353 AEGEPIPEITWKRSSDGMIFYDG----DKSQDGRIESTGHH--GKSSLHIKSVM----------L 401

  Fly   487 AEAGPTTLSCRTK-GGRQK 504
            ::||.......:: ||.||
Frog   402 SDAGRYDCEAASRIGGHQK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	27/110 (25%)
		ig	102..195	CDD:278476	24/92 (26%)
		IG_like	219..307	CDD:214653	18/89 (20%)
		Ig	221..307	CDD:299845	18/87 (21%)
		Ig	311..404	CDD:299845	30/100 (30%)
		IG_like	327..405	CDD:214653	25/77 (32%)
ncam2	XP_012811963.1	Ig	50..141	CDD:386229	27/111 (24%)
		IG_like	150..234	CDD:214653	18/95 (19%)
		Ig	237..330	CDD:386229	29/100 (29%)
		Ig	329..426	CDD:386229	21/108 (19%)
		IG_like	442..520	CDD:214653
		FN3	525..617	CDD:238020
		fn3	623..706	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11918
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010