DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-beta and lrit3b

DIOPT Version :9

Sequence 1:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_009305418.1	Gene:	lrit3b / 100144406	ZFINID:	ZDB-GENE-070424-130	Length:	487	Species:	Danio rerio

Alignment Length:	405	Identity:	66/405 - (16%)
Similarity:	122/405 - (30%)	Gaps:	169/405 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 IPLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKA-----ILAIHEHVITNN 161
            |||  :.:...|:.|:.    :|..:|:|...:...|  .|:.:|:..     :|.:.:
Zfish   175 IPL--LAVRYLRNVTYL----DLSSNRLSTLANDLTA--LWLFSDSNQTQRSFVLGLQD------ 225

  Fly   162 DRLSVQHNDYNTWTLNIRGVKMEDAGK------------YMCQVNTDPMKM-----QTATLEVVI 209
                      |.|..:.|...:.|..:            ..|   ::|:.:     |:..|....
Zfish   226 ----------NPWVCDCRLSTLLDISRGPESSLVLLDRFLTC---SEPLDLAGVPFQSVELSRCR 277

  Fly   210 PPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEML 274
            .|.::...|....::  |.:..|.|.|.|||.|.:.|.:...|.:. ..|..::|:: |::.|
Zfish   278 RPYVVTSATKITALL--GSTVLLRCEATGHPTPALMWIKSAKRNLY-NQGCCKQTQS-SLDTE-- 336

  Fly   275 TLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASPK 339
                                                   :.|.:|.|           .|:.||:
Zfish   337 ---------------------------------------RFPKKLFG-----------YVQESPR 351

  Fly   340 AINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEGTIRL 404
            ....|.                           ::.:..:..||.|.|:|.::|..|.:|..:
Zfish   352 VGVRWS---------------------------VVSLNGISYSDAGEYRCRAQNMAGISEAVV-- 387

  Fly   405 YEMERPGKKILRDDDLNEVS--------KNEVVQKDTRSEDGS-------------RNLNGRLYK 448
                          .||.|.        ||...|:.|...|..             ||:.|.|..
Zfish   388 --------------SLNVVGVMAEYTDFKNSDQQQTTTKSDSKRTKPKQKSKAMMPRNMTGSLSP 438

  Fly   449 DRAPDQHPASGSDQL 463
            .:...:.|.:|.|::
Zfish   439 LKRVLKTPKAGRDKM 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	20/128 (16%)
		ig	102..195	CDD:278476	17/109 (16%)
		IG_like	219..307	CDD:214653	14/87 (16%)
		Ig	221..307	CDD:299845	14/85 (16%)
		Ig	311..404	CDD:299845	15/92 (16%)
		IG_like	327..405	CDD:214653	12/77 (16%)
lrit3b	XP_009305418.1	LRRNT	51..92	CDD:214470
		leucine-rich repeat	69..89	CDD:275380
		LRR_8	112..172	CDD:290566
		leucine-rich repeat	114..137	CDD:275378
		leucine-rich repeat	138..161	CDD:275378
		LRR_8	160..214	CDD:290566	11/46 (24%)
		LRR_4	160..201	CDD:289563	8/31 (26%)
		leucine-rich repeat	162..185	CDD:275378	3/11 (27%)
		leucine-rich repeat	186..199	CDD:275378	4/16 (25%)
		leucine-rich repeat	215..230	CDD:275378	3/30 (10%)
		Ig	278..391	CDD:299845	32/211 (15%)
		I-set	279..391	CDD:254352	32/210 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900