DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA8 and Hsp70Bbb

DIOPT Version :9

Sequence 1:NP_006588.1 Gene:HSPA8 / 3312 HGNCID:5241 Length:646 Species:Homo sapiens
Sequence 2:NP_788663.1 Gene:Hsp70Bbb / 50022 FlyBaseID:FBgn0051354 Length:641 Species:Drosophila melanogaster


Alignment Length:643 Identity:483/643 - (75%)
Similarity:554/643 - (86%) Gaps:4/643 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFD 69
            ||:|||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||.|||||
  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFD 66

Human    70 AKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAY 134
            |||||||::||..:..|||||||.||:|.|:||:.||||||:|.|.|||:||||||||||.||||
  Fly    67 AKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131

Human   135 LGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFD 199
            ||:::|:||:||||||||||||||||||.|||||||||||||||||:||||||.:..||||||||
  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKDERNVLIFD 196

Human   200 LGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL 263
            |||||||||||||::| :|||:||||||||||||||||:|.|...|||||:|||:..|.||:|||
  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRL 261

Human   264 RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDK 328
            |||.|||||||||||:|:||||:|:||.||||.::|||||||.|||||.||.||||||.|||:||
  Fly   262 RTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDK 326

Human   329 SQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLL 393
            .||||||||||||||||:|.|||:||:||.||.||||||||||||||||||||||:|..:||:||
  Fly   327 GQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLL 391

Human   394 LDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGK 458
            :||.||||||||||||||.||:||..||.|||:||:|||||||||.|||||||||||||||.||.
  Fly   392 VDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGT 456

Human   459 FELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAE 523
            |:|:|||||||||||||||||:||||||||||.:.||||...|||.|||||||:.:|:|||.|||
  Fly   457 FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAE 521

Human   524 KYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAE 588
            ||..||||.|.:::|:|:||||.||:|.:|| :...||:::.||..:||||||.|.|||.|.|||
  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTTAE 585

Human   589 KEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD 646
            ||||:|:.:||.:.|:||:||::|...|..|| ||...|..|...|| .||||:||||
  Fly   586 KEEFDHKMEELTRHCSPIMTKMHQQGAGAAGG-PGANCGQQAGGFGG-YSGPTVEEVD 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA8NP_006588.1 PTZ00009 1..613 CDD:240227 465/608 (76%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000305|PubMed:27474739 2..386 309/381 (81%)
Interaction with BAG1 186..377 150/191 (79%)
Substrate-binding domain (SBD). /evidence=ECO:0000305|PubMed:27474739 394..509 92/114 (81%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 15/31 (48%)
Hsp70BbbNP_788663.1 PTZ00009 2..641 CDD:240227 481/641 (75%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 304/375 (81%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.730

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