DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA8 and Hsp68

DIOPT Version :9

Sequence 1:	NP_006588.1	Gene:	HSPA8 / 3312	HGNCID:	5241	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_524474.1	Gene:	Hsp68 / 42852	FlyBaseID:	FBgn0001230	Length:	635	Species:	Drosophila melanogaster

Alignment Length:	646	Identity:	462/646 - (71%)
Similarity:	548/646 - (84%)	Gaps:	16/646 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     5 PAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFD 69
            ||:|||||||||||||||:|||||||||||||||||||||||:||||||||||||||||.|:|||
  Fly     2 PAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFD 66

Human    70 AKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAY 134
            |||||||||||:.:|.|:|||||.|:||.|:||:.||:||..|.|.|||:||||||||||.||||
  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131

Human   135 LGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFD 199
            ||.||.:||:||||||||||||||||||.|||:|||||||||||||:||||||.:..||||||||
  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKNLKGERNVLIFD 196

Human   200 LGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL 263
            |||||||||||||::| :|||:||||||||||||||||:||||..|||||:|||:..|.||:|||
  Fly   197 LGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALRRL 261

Human   264 RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDK 328
            |||.|||||||||||:||:|||:||||.|||:.::|||||||..||||.||:||||||:|||:||
  Fly   262 RTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKMDK 326

Human   329 SQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLL 393
            |||||||||||||||||:|.|||:||.||.||.|||||||||||||:||||||||||..::|:||
  Fly   327 SQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDVLL 391

Human   394 LDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGK 458
            :||.||||||||||||||.||:||:.||.||::|||||:||||.|.|||:|||||:|||||:||.
  Fly   392 VDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVLGT 456

Human   459 FELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAE 523
            |:|||:||||||||:|:||||:||||||||:|.::.||....|||.|||||||:.||:||:.|||
  Fly   457 FDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSEAE 521

Human   524 KYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAE 588
            ||..|||:.|.:::::|.||:|.|.:|...|:.  ..:|:..||..|:::|:|.:.|||.|.|||
  Fly   522 KYAEEDERHRQRIAARNQLETYLFGVKEAAENG--GDRISAADKSSIVERCSEAMKWLDSNTTAE 584

Human   589 KEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSG---GASSGPTIEEVD 646
            |||:|::.||||:.|:||:||:::          ||..|..||..|   |...|||:||||
  Fly   585 KEEYEYKLKELEQFCSPIMTKMHK----------GGGDGQQAPNFGQQAGGYKGPTVEEVD 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	448/608 (74%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305\|PubMed:27474739	2..386		311/381 (82%)
		Interaction with BAG1	186..377		151/191 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305\|PubMed:27474739	394..509		83/114 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..646		12/34 (35%)
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	460/644 (71%)
Hsp68	NP_524474.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	305/375 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730