Protein Alignment HSPA8 and Hsc70-4

DIOPT Version :10

• Sequence 1: NP_006588.1
• Gene: HSPA8 / 3312
• HGNCID: 5241
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 555/654 - (84%)
• Similarity: 600/654 - (91%)
• Gaps: 11/654 - (1%)

Human     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
  Fly     1 MSKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQ 65

Human    66 TVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEI 130
            |:|||||||||:||||.||||||||||.||:..|:||::|.||.|.|:|:|||:||||||||||.
  Fly    66 TIFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKET 130

Human   131 AEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195
            |||||||||||||:||||||||||||||||||||||||||||||||||||||||||||...||||
  Fly   131 AEAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNV 195

Human   196 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAV 260
            |||||||||||||||:|:|||||||||||||||||||||||:|.||:.|||||||||::.||||:
  Fly   196 LIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRAL 260

Human   261 RRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAK 325
            |||||||||||||||||||||||||||:||.||||||||||||||||||||.|:|||||||||||
  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAK 325

Human   326 LDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQD 390
            ||||.|||||||||||||||:|:||||.|||||||||||||||||||||||||||.||||:.|||
  Fly   326 LDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQD 390

Human   391 LLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
  Fly   391 LLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455

Human   456 LGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQ 520
            ||||||:||||||||||||||||||||||||||:|:::||.|||||||||||||||||||||||.
  Fly   456 LGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVN 520

Human   521 EAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQ 585
            |||||:.|||||::.:::||.||||.||||||::::.|:.||:|.|:..|||||||.|.|||.||
  Fly   521 EAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDANQ 585

Human   586 TAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGG--------GAPPSGGASSGPTI 642
            .|:|||:||:|||||.|||||||||||.||..||||||| |||        ||..:|||  ||||
  Fly   586 LADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGG-PGGMPGAAGAAGAAGAGGA--GPTI 647

Human   643 EEVD 646
            ||||
  Fly   648 EEVD 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	529/611 (87%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305|PubMed:27474739	2..386		341/383 (89%)
		Interaction with BAG1	186..377		169/190 (89%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305|PubMed:27474739	394..509		107/114 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..646		23/39 (59%)
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	528/610 (87%)