DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA8 and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_006588.1	Gene:	HSPA8 / 3312	HGNCID:	5241	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	647	Identity:	461/647 - (71%)
Similarity:	537/647 - (82%)	Gaps:	16/647 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65
            |.|.||:|||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||..|
  Fly     1 MGKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65

Human    66 TVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEI 130
            |||||||||||:|||..:|.|:|.|||.|:|:.|:||::||:|||.|.|.|||:||||||||:||
  Fly    66 TVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREI 130

Human   131 AEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195
            ||.|||..|.:|||||||||||||||||||||:|||||||||||||||||:||||||.:..||||
  Fly   131 AEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNV 195

Human   196 LIFDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRA 259
            |||||||||||||:|:|::| :||||:|||||||||||||||:||||..|||||||.||..|.||
  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260

Human   260 VRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDA 324
            :||||||||||||||||||:||:|||:|:||||||:.|:||||||||.||||.|:.|||:||.||
  Fly   261 LRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDA 325

Human   325 KLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQ 389
            |:||..|||:||||||||||||||||||.|.||:||.|||||||||||||||||||:|..|..:|
  Fly   326 KMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQ 390

Human   390 DLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454
            ||||:||.||||||||||||||.|::||..||.||.|.||||||||..|.|||||||||||||||
  Fly   391 DLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNN 455

Human   455 LLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMV 519
            |||.|.||||||||||||||||.||::|:|||||:|.|.||||..||||:||||||||.:|:||:
  Fly   456 LLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRML 520

Human   520 QEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKN 584
            .||||||.||::||::|.|||:||:|.:..:..|:|.. .|.:::.::.|:.|||:...:|||||
  Fly   521 SEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWLDKN 584

Human   585 QTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD 646
            ..|||||||...||.:::|.||::|::       ||..|       ..|.|..|.||:||||
  Fly   585 SLAEKEEFESHLKECQRICTPIMSKIH-------GGKKG-------KSSMGKGSHPTVEEVD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	449/612 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305\|PubMed:27474739	2..386		303/384 (79%)
		Interaction with BAG1	186..377		151/191 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305\|PubMed:27474739	394..509		89/114 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..646		10/31 (32%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	459/645 (71%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	299/375 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730