DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA8 and Hsc70-1

DIOPT Version :9

Sequence 1:NP_006588.1 Gene:HSPA8 / 3312 HGNCID:5241 Length:646 Species:Homo sapiens
Sequence 2:NP_524063.1 Gene:Hsc70-1 / 39542 FlyBaseID:FBgn0001216 Length:641 Species:Drosophila melanogaster


Alignment Length:648 Identity:519/648 - (80%)
Similarity:583/648 - (89%) Gaps:9/648 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65
            |.|.|||||||||||||||||||||||||||||||||||||||||::||||||||||||||||.|
  Fly     1 MPKLPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNN 65

Human    66 TVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEI 130
            |:||||||||||||||.||||||||||.|..:.|:|:::||||||.||||||||||||||||:|.
  Fly    66 TIFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRET 130

Human   131 AEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195
            ||||||.|||:|||||||||||||||||||||.||||||||||||||||||||||||:..:||||
  Fly   131 AEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNV 195

Human   196 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAV 260
            |||||||||||||:|||||||||||:|||||||||||||||:||||:.||:||||||:.:||||:
  Fly   196 LIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRAL 260

Human   261 RRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAK 325
            |||||||||||||||||||||||||||:||:|||||:|||||||||.||||||::||.|||||||
  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325

Human   326 LDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQD 390
            :||.||||||||||||||||:|:||||||||||||||||||||||||||||||||.|||||.|||
  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390

Human   391 LLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            |||||||||||||||||||||.||||||||||||||.||||:||||||||||:|||||||:|||.
  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455

Human   456 LGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQ 520
            ||||||:.||||||||||:||||||||||||||:|::|||||||:|||||||||||||||||||.
  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520

Human   521 EAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQ 585
            :||.|:..||:|||::::||.||||.|.:::|::||.|..:.:..|::.|..:.:|.|.|||.||
  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585

Human   586 TAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFP--GGGAPPSGGASSGPTIEEVD 646
            .||::||||:|:|||::|:||||:|||.||..|       |  .||:.|.....|||||||||
  Fly   586 LAERQEFEHKQQELERICSPIITRLYQGAGMAP-------PPTAGGSNPGATGGSGPTIEEVD 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA8NP_006588.1 PTZ00009 1..613 CDD:240227 502/611 (82%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000305|PubMed:27474739 2..386 335/383 (87%)
Interaction with BAG1 186..377 165/190 (87%)
Substrate-binding domain (SBD). /evidence=ECO:0000305|PubMed:27474739 394..509 101/114 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 14/33 (42%)
Hsc70-1NP_524063.1 PTZ00009 1..641 CDD:240227 517/646 (80%)
HSPA1-2_6-8-like_NBD 6..381 CDD:212675 329/374 (88%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H68524
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S49
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D180577at33208
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 1 1.000 - - otm40336
orthoMCL 1 0.900 - - OOG6_100083
Panther 1 1.100 - - O PTHR19375
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X148
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.780

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