Protein Alignment HSPA8 and Hsc70-1

DIOPT Version :10

• Sequence 1: NP_006588.1
• Gene: HSPA8 / 3312
• HGNCID: 5241
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_524063.1
• Gene: Hsc70-1 / 39542
• FlyBaseID: FBgn0001216
• Length: 641
• Species: Drosophila melanogaster
• Alignment Length: 648
• Identity: 519/648 - (80%)
• Similarity: 583/648 - (89%)
• Gaps: 9/648 - (1%)

Human     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65
            |.|.|||||||||||||||||||||||||||||||||||||||||::||||||||||||||||.|
  Fly     1 MPKLPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTESERLIGDAAKNQVAMNPNN 65

Human    66 TVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEI 130
            |:||||||||||||||.||||||||||.|..:.|:|:::||||||.||||||||||||||||:|.
  Fly    66 TIFDAKRLIGRRFDDATVQSDMKHWPFEVFAENGKPRIRVEYKGERKSFYPEEVSSMVLTKMRET 130

Human   131 AEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195
            ||||||.|||:|||||||||||||||||||||.||||||||||||||||||||||||:..:||||
  Fly   131 AEAYLGGTVTDAVVTVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDKQGTSERNV 195

Human   196 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAV 260
            |||||||||||||:|||||||||||:|||||||||||||||:||||:.||:||||||:.:||||:
  Fly   196 LIFDLGGGTFDVSVLTIEDGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFQRKHKKDLGQNKRAL 260

Human   261 RRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAK 325
            |||||||||||||||||||||||||||:||:|||||:|||||||||.||||||::||.|||||||
  Fly   261 RRLRTACERAKRTLSSSTQASIEIDSLFEGVDFYTSVTRARFEELNGDLFRGTMEPVAKALRDAK 325

Human   326 LDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQD 390
            :||.||||||||||||||||:|:||||||||||||||||||||||||||||||||.|||||.|||
  Fly   326 MDKGQIHDIVLVGGSTRIPKVQRLLQDFFNGKELNKSINPDEAVAYGAAVQAAILHGDKSEAVQD 390

Human   391 LLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNL 455
            |||||||||||||||||||||.||||||||||||||.||||:||||||||||:|||||||:|||.
  Fly   391 LLLLDVTPLSLGIETAGGVMTTLIKRNTTIPTKQTQIFTTYADNQPGVLIQVFEGERAMTRDNNS 455

Human   456 LGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQ 520
            ||||||:.||||||||||:||||||||||||||:|::|||||||:|||||||||||||||||||.
  Fly   456 LGKFELSAIPPAPRGVPQVEVTFDIDANGILNVTALEKSTGKENRITITNDKGRLSKEDIERMVN 520

Human   521 EAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQ 585
            :||.|:..||:|||::::||.||||.|.:::|::||.|..:.:..|::.|..:.:|.|.|||.||
  Fly   521 DAEAYRQADEQQRDRINAKNQLESYCFQLRSTLDDEHLSSRFSPADRETIQQRSSETIAWLDANQ 585

Human   586 TAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFP--GGGAPPSGGASSGPTIEEVD 646
            .||::||||:|:|||::|:||||:|||.||..|       |  .||:.|.....|||||||||
  Fly   586 LAERQEFEHKQQELERICSPIITRLYQGAGMAP-------PPTAGGSNPGATGGSGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	502/611 (82%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305|PubMed:27474739	2..386		335/383 (87%)
		Interaction with BAG1	186..377		165/190 (87%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305|PubMed:27474739	394..509		101/114 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..646		14/33 (42%)
Hsc70-1	NP_524063.1	PTZ00009	1..641	CDD:240227	517/646 (80%)