Protein Alignment HSPA8 and CG7182

DIOPT Version :9

• Sequence 1: NP_006588.1
• Gene: HSPA8 / 3312
• HGNCID: 5241
• Length: 646
• Species: Homo sapiens
• Sequence 2: NP_001286979.1
• Gene: CG7182 / 38944
• FlyBaseID: FBgn0035878
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 136/523 - (26%)
• Similarity: 236/523 - (45%)
• Gaps: 73/523 - (13%)

Human     5 PAVGIDLGTTYSCVG-VFQHGKVEIIANDQGNRTTPSYVAFTDTERL-IGDAAKNQVAMNPTNTV 67
            |..||.:|.:..|:. |...||.|:|||.||:|.:.:.:.:.....: .|..||.::|..|...|
  Fly     3 PRFGIKIGNSTLCIAHVRADGKAEVIANKQGDRVSQACLLWDGASEIECGLTAKQKMANRPRQAV 67

Human    68 ----------------------------FDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQ 104
                                        ||.:.|:.|.  :..|.||.:.....||
  Fly    68 AHSFQLLQPKEELTEEKLSSALREIPCDFDKEELVFRM--EHTVPSDREDQDDRVV--------- 121

Human   105 VEYKGETKSFYPEEVSSMVLTKMKEIAEAYL--GKTVTNAVVTVPAYFNDSQRQATKDAGTIAGL 167
                  ||.....:|:..:|....|:|..|.  |:....||:::|:|:..|..:...||...||.
  Fly   122 ------TKDLSAYQVTVELLRAELELAHQYHTDGEQAPIAVLSIPSYYPASAYKLLADAAQTAGF 180

Human   168 NVLRIINEPTAAAIAYGL-DKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGE 231
            :|.:||.|||||.:.|.: :::....|:||....||...|::..::::|:|...:|.|...:||.
  Fly   181 HVAQIITEPTAAVLGYSIGEEQTEQRRHVLTIKCGGLYSDIAFYSVQNGLFVQLATFGPFPIGGR 245

Human   232 DFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTS 296
            .|...:|.....||:||:|.|..|::|:|.::|||....|..|::.....:.||||.:|:|:...
  Fly   246 QFTEALVQFICEEFRRKYKLDPHESRRSVAKIRTAAANCKHILTTMPSTQLYIDSLMDGVDYNAQ 310

Human   297 ITRARFEELNADLFRGTLDPVEKALRDAKLDK---SQIHDIVLVGGSTRIPKIQKLLQDFFNGKE 358
            ::|||||.|...:....:..:.:.:..|:.:.   |:|.||||:|.:.:|||:|..:...|...:
  Fly   311 MSRARFESLIQPVINNLIQQLGECVEQAQKEHPGLSKIDDIVLLGATMQIPKLQAAVGARFPDAK 375

Human   359 LNKSINPDEAVAYGAAVQAAILSGDKSENV----------QDLLLLDVTPLSLGIETAGGVMTVL 413
            |:.|.:.||.||.|.|.||..|.....:.:          .||.:..      |.:.:..  .::
  Fly   376 LHNSHSADEVVAIGCARQAVCLIDPLEQQLHKEEDCVVAEDDLFIWH------GNDESNA--KLV 432

Human   414 IKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTF 478
            :.|.:.:|.|...:.....:.:...:.:.....:..|.::.:|.:...:.||  ..|:.|:||..
  Fly   433 LGRGSVLPAKIRISLPQSEEGKGDDVSKAAASFKLRTGESEILARLPDSTIP--EDGLYQLEVEV 495

Human   479 DID 481
            |:|
  Fly   496 DVD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	136/523 (26%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305|PubMed:27474739	2..386		120/416 (29%)
		Interaction with BAG1	186..377		61/193 (32%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305|PubMed:27474739	394..509		14/88 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..646
CG7182	NP_001286979.1	NBD_sugar-kinase_HSP70_actin	5..394	CDD:302596	116/405 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810