DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA8 and Hsc70-5

DIOPT Version :9

Sequence 1:	NP_006588.1	Gene:	HSPA8 / 3312	HGNCID:	5241	Length:	646	Species:	Homo sapiens
Sequence 2:	NP_001286414.1	Gene:	Hsc70-5 / 36583	FlyBaseID:	FBgn0001220	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	323/651 - (49%)
Similarity:	429/651 - (65%)	Gaps:	27/651 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     3 KGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNT 66
            ||..:|||||||.||:.|.:..:.::|.|.:|.|||||:|||| |.|||:|..||.|...|..||
  Fly    51 KGAVIGIDLGTTNSCLAVMEGKQAKVIENAEGARTTPSHVAFTKDGERLVGMPAKRQAVTNSANT 115

Human    67 VFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIA 131
            .:..||||||||||..|:.|:.:..:.||. |......|. ..:.|.:.|.::.:.:|.||||.|
  Fly   116 FYATKRLIGRRFDDPEVKKDITNLSYKVVK-ASNGDAWVS-STDGKVYSPSQIGAFILMKMKETA 178

Human   132 EAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVL 196
            ||||...|.||||||||||||||||||||||.||||||||:||||||||:|||:||.  .::.:.
  Fly   179 EAYLNTPVKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVINEPTAAALAYGMDKT--EDKIIA 241

Human   197 IFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVR 261
            ::||||||||:|||.|:.|:||||||.|||.||||||||.:||..:||||:....||.::..|::
  Fly   242 VYDLGGGTFDISILEIQKGVFEVKSTNGDTLLGGEDFDNHIVNFLVAEFKKDSGIDIRKDNIAMQ 306

Human   262 RLRTACERAKRTLSSSTQASIEIDSLYEGID------FYTSITRARFEELNADLFRGTLDPVEKA 320
            ||:.|.|:||..||||.|..|.:.  |..:|      ....:||::.|.|..||.:.|:.|.:||
  Fly   307 RLKEAAEKAKCELSSSQQTDINLP--YLTMDAAGPQHMNLKLTRSKLESLVGDLIKRTIQPCQKA 369

Human   321 LRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKS 385
            |.||::.||:|.:::||||.||:||:|..:|:.| |::.::|:|||||||.|||||..:|:||
  Fly   370 LSDAEVSKSEIGEVLLVGGMTRMPKVQSTVQELF-GRQPSRSVNPDEAVAVGAAVQGGVLAGD-- 431

Human   386 ENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMT 450
              |.|:||||||||||||||.|||.|.||.||||||||::|.|:|.||.|..|.|:|::|||.|.
  Fly   432 --VTDVLLLDVTPLSLGIETLGGVFTRLISRNTTIPTKKSQVFSTASDGQTQVEIKVHQGEREMA 494

Human   451 KDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDI 515
            .||.|||.|.|.||||||||||||||.||||||||::|||.||.||||.:|.| ...|.|||::|
  Fly   495 NDNKLLGSFTLVGIPPAPRGVPQIEVVFDIDANGIVHVSAKDKGTGKEQQIVI-QSSGGLSKDEI 558

Human   516 ERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINW 580
            |.|:::||:|...|:::|:.:...|..||...:.:..:|:.|.|  :..|:.:|:..:..::...
  Fly   559 ENMIKKAEEYATADKQKRELIEIVNQGESIVHDTETKMEEFKSQ--LPAEECEKLKKEIADLRTL 621

Human   581 LDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGAS--SGPTIE 643
            |...:||:.||.......|::..    .||::.|............|.|:..|..:|  ||...:
  Fly   622 LANKETADLEEVRKATSSLQQSS----LKLFELAYKKMSAERESNAGAGSSDSSSSSDTSGEAKK 682

Human   644 E 644
            |
  Fly   683 E 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA8	NP_006588.1	PTZ00009	1..613	CDD:240227	315/616 (51%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000305\|PubMed:27474739	2..386		204/389 (52%)
		Interaction with BAG1	186..377		95/196 (48%)
		Substrate-binding domain (SBD). /evidence=ECO:0000305\|PubMed:27474739	394..509		79/114 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..646		8/33 (24%)
Hsc70-5	NP_001286414.1	dnaK	51..666	CDD:234715	317/632 (50%)
		HSPA9-like_NBD	51..428	CDD:212683	201/383 (52%)
		Syntaphilin	<566..>642	CDD:291936	18/77 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820