DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mst and MSTO1

DIOPT Version :9

Sequence 1:	NP_001285518.1	Gene:	mst / 33119	FlyBaseID:	FBgn0020272	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_060586.2	Gene:	MSTO1 / 55154	HGNCID:	29678	Length:	570	Species:	Homo sapiens

Alignment Length:	594	Identity:	178/594 - (29%)
Similarity:	272/594 - (45%)	Gaps:	67/594 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REILTFQFGTYANYVGTHFWNQQEANFRYGDESEQVAEEQLPNNDILYREGRNDLNRTTYTPRLL 69
            ||:||.|.|.:|.:||.|:||||:|......:|::...|..|  |:|||.||....:.||||||:
Human     6 REVLTLQLGHFAGFVGAHWWNQQDAALGRATDSKEPPGELCP--DVLYRTGRTLHGQETYTPRLI 68

  Fly    70 SVDLSGTLGHLPVTGELY------------GNFVQRDEELLPLSTGEELEQVRKRAEESGVCSPE 122
            .:||.|:|..|...|.||            |......|||.|.:     ..::......||.|.:
Human    69 LMDLKGSLSSLKEEGGLYRDKQLDAAIAWQGKLTTHKEELYPKN-----PYLQDFLSAEGVLSSD 128

  Fly   123 ---QLEVQEQSKASISEYQRDLLKNAVVPEKNYQLAATANSWVDFLYARYHPRTLNVLPGLIRDP 184
               :::.....|.|      ..|..|..|:......|:...|.|||....|||::.::.....|.
Human   129 GVWRVKSIPNGKGS------SPLPTATTPKPLIPTEASIRVWSDFLRVHLHPRSICMIQKYNHDG 187

  Fly   185 TAQALGTYSAGTEMWQEVSFNEEFCDRIRLYVEECDGLQGFHVLFDIDDGFGGLAGKCLEHLNDE 249
            .|..|..:..|..:.:|..:.||..||:..||||||.||||.:|.|:.|||.|:..|..|.|.||
Human   188 EAGRLEAFGQGESVLKEPKYQEELEDRLHFYVEECDYLQGFQILCDLHDGFSGVGAKAAELLQDE 252

  Fly   250 YSRASF----ALPLHYPRITSYPQADTRLSHSIRVVNNVLGYHQLSEQALMFTPLSTLETIWRNN 310
            ||....    .||..|.|    .:|...:   .|::|...|...|:..:.:..|||.      ..
Human   253 YSGRGIITWGLLPGPYHR----GEAQRNI---YRLLNTAFGLVHLTAHSSLVCPLSL------GG 304

  Fly   311 NLKSR-----SLPGLQWETDNLYQTSALLAAFFDTATLSYRLRQTPESLLRFCECVTPAGRKMTA 370
            :|..|     |.|.|.::....:..||:||...||.|:.|||..:|.|::...:.::..|:|:..
Human   305 SLGLRPEPPVSFPYLHYDATLPFHCSAILATALDTVTVPYRLCSSPVSMVHLADMLSFCGKKVVT 369

  Fly   371 AGLALPFGLREGQDLIEFLDQSGDHALLTQLTPGCEP-GTSYVVQSVTARGIPAERLKRPRELA- 433
            ||..:||.|..||.|.:.|.|.|.....|.|:...|| ||....|||..|||  :|.....:|.
Human   370 AGAIIPFPLAPGQSLPDSLMQFGGATPWTPLSACGEPSGTRCFAQSVVLRGI--DRACHTSQLTP 432

  Fly   434 GDQLRMAAYSCDSISHMLQLYYQCTYHGSVTNAAATPLPLKTQLPFPYEMFAA----GISRDGYR 494
            |.....|.::|.:...:|..|.|....|.::::.....|.:...|:|: :|::    |:..||
Human   433 GTPPPSALHACTTGEEILAQYLQQQQPGVMSSSHLLLTPCRVAPPYPH-LFSSCSPPGMVLDG-- 494

  Fly   495 LPEGAERETGSRVDSAPMLAAVQNSTKLGEHLDNVHAQSHRVQLAKLQAYSNSGLERDEYDTALD 559
            .|:||      .|:|.|:..|:.:|:.|.:.|:.:.....::.|.:..::.::|:|.|:....|.
Human   495 SPKGA------AVESIPVFGALCSSSSLHQTLEALARDLTKLDLRRWASFMDAGVEHDDVAELLQ 553

  Fly   560 QLLEFRDLY 568
            :|......|
Human   554 ELQSLAQCY 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mst	NP_001285518.1	misato	5..570	CDD:276964	178/594 (30%)
MSTO1	NP_060586.2	misato	6..563	CDD:276964	178/594 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157603
Domainoid	1	1.000	95	1.000	Domainoid score	I7436
eggNOG	1	0.900	-	-		E1_KOG2530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41228
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3590
Isobase	1	0.950	-	0	Normalized mean entropy	S6100
OMA	1	1.010	-	-		QHG48476
OrthoDB	1	1.010	-	-		D1321917at2759
OrthoFinder	1	1.000	-	-		FOG0005869
OrthoInspector	1	1.000	-	-		oto91330
orthoMCL	1	0.900	-	-		OOG6_103867
Panther	1	1.100	-	-	LDO	PTHR13391
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2091
SonicParanoid	1	1.000	-	-		X4263
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750