DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mst and msto1

DIOPT Version :9

Sequence 1:	NP_001285518.1	Gene:	mst / 33119	FlyBaseID:	FBgn0020272	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_956181.1	Gene:	msto1 / 334306	ZFINID:	ZDB-GENE-030131-6238	Length:	591	Species:	Danio rerio

Alignment Length:	609	Identity:	171/609 - (28%)
Similarity:	262/609 - (43%)	Gaps:	77/609 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REILTFQFGTYANYVGTHFWNQQEANFRYGDESEQVAEEQLPNNDILYREGRNDLNRTTYTPRLL 69
            ||::|.|.|.|:|::|||:||.|:|...| |......|.|   :|:|:|||.......||||||:
Zfish     6 REVVTLQLGHYSNFIGTHWWNLQDAGLVY-DADVPAGELQ---SDVLFREGLTLAGHVTYTPRLI 66

  Fly    70 SVDLSGTLGHLPVTGELY------------GNFVQRDE----------ELLPLSTGEELEQVRKR 112
            ::||.|:|..|...|.||            |..:...|          ||..|.||..|.:....
Zfish    67 AIDLKGSLQTLRKEGSLYDTENENSAFTWDGQIMTHQESPPSKNRFLQELDNLDTGGVLAEPDFN 131

  Fly   113 AEESGV--CS-PEQLEVQEQSKASISEYQRDLLKNAVVPEKNYQLAATANSWVDFLYARYHPRTL 174
            ...|.|  || |......|...:|:...|           |:|:|..:...|.|||....||||:
Zfish   132 HLTSSVDNCSVPGASVAVETINSSLERIQ-----------KSYRLEGSVRVWSDFLRLHLHPRTI 185

  Fly   175 NVLPGLIRDPTAQALGTYSAGTEMWQEVSFNEEFCDRIRLYVEECDGLQGFHVLFDIDDGFGGLA 239
            :|:.....|..::.|..:..|..:.|. ...|:..||:..::||||.||||.||.|:.|||.||.
Zfish   186 SVINQYNHDGESERLEVFGQGEALLQG-QVLEDLEDRLHFFIEECDYLQGFQVLCDLTDGFSGLG 249

  Fly   240 GKCLEHLNDEYSRASF----ALPLHYPRITSYPQADTRLSHSIRVVNNVLGYHQLSEQALMFTPL 300
            .|..|:|.|.|.....    ..|:::|..:|...    |.|   ::|..||..|::..:.:|.||
Zfish   250 SKVTEYLQDSYGGRGILTWGVAPVNHPDTSSMKD----LYH---MMNCALGTLQMANHSSLFCPL 307

  Fly   301 STLETIWRNNNLKSRSLPGLQWETDNLYQTSALLAAFFDTATLSYRLRQTPESLLRFCECVTPAG 365
            :....:.|... ...:.|.|..:....|.:|::||...|..|:|||:|....::.:..:.:|.:|
Zfish   308 TLRGGLCRRPP-PPTAFPLLNCDPLLWYHSSSVLALALDALTVSYRMRHCSATMWQLSDALTTSG 371

  Fly   366 RKMTAAGLALPFGLREGQDLIEFLDQSGDHALLTQLT--PGCEPGTSYVVQSVTARGIPAERLKR 428
            ||:.:|..::||.:..|..|.:.||...:......|:  |..........||||.:|:..:.|.
Zfish   372 RKVVSAYGSVPFPMMLGGCLPDALDAFSNAVPWRSLSACPEISDRRFCFSQSVTLKGVDEQSLV- 435

  Fly   429 PRELAGDQLRMAAYSCDSISHMLQLYYQCTYHGSVTNAAATPLPLKTQL---------PFPYEMF 484
            .|.|.|.:.....:...|...:|..|.:..|..|         ||..||         ||| ::|
Zfish   436 SRLLPGMEAPSPLHYERSGEDVLSAYVRSHYPSS---------PLAVQLVSSGSKVTPPFP-QIF 490

  Fly   485 AAGISRDGYRLPEGAERETG-SRVDSAPMLAAVQNSTKLGEHLDNVHAQSHRVQLAKL-QAYSNS 547
            :..:|..|:........... ..|...|:|.::|:|..:|..|..:......:.|.:: .::...
Zfish   491 SPSLSAQGFLQSHSTPASPSCPPVSCLPVLTSLQSSPAVGLQLSELQRACASLDLRRVAPSFLTH 555

  Fly   548 GLERDEYDTALDQLLEFRDLYADS 571
            |.|..|....|:||......|..|
Zfish   556 GPEHAEISEYLEQLRNLAHCYRQS 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mst	NP_001285518.1	misato	5..570	CDD:276964	170/606 (28%)
msto1	NP_956181.1	misato	6..577	CDD:276964	169/605 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593405
Domainoid	1	1.000	89	1.000	Domainoid score	I7882
eggNOG	1	0.900	-	-		E1_KOG2530
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41228
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3915
OMA	1	1.010	-	-		QHG48476
OrthoDB	1	1.010	-	-		D1321917at2759
OrthoFinder	1	1.000	-	-		FOG0005869
OrthoInspector	1	1.000	-	-		oto39320
orthoMCL	1	0.900	-	-		OOG6_103867
Panther	1	1.100	-	-	LDO	PTHR13391
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2091
SonicParanoid	1	1.000	-	-		X4263
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800