DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hlc and DDX18

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_006764.3	Gene:	DDX18 / 8886	HGNCID:	2741	Length:	670	Species:	Homo sapiens

Alignment Length:	492	Identity:	129/492 - (26%)
Similarity:	220/492 - (44%)	Gaps:	105/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQKILNSKLNASE 80
            :::..|||:.::|:...|.||..:|..||||:|::..|:||||||..:.:|.::.|:..:. ...
Human   186 VNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPAVELIVKLRF-MPR 249

  Fly    81 QYVSAVVLAPTKELCRQSRKVIEQL----VESCGKVVRVADIADSSNDTVTQRHALSESPDIVVA 141
            .....::|:||:||..|:..|:::|    |.:.|.:     :..|:.....|:  |....:|:||
Human   250 NGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLI-----MGGSNRSAEAQK--LGNGINIIVA 307

  Fly   142 TPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHLPPIYQAVLVSATLT---D 203
            ||..||.:.:.......|:::.||:||||.:...|:|::.|::||.||...|.:|.|||.|   :
Human   308 TPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPTRRQTMLFSATQTRKVE 372

  Fly   204 DVVRMKGLCLNNPVTLKLEEPELVPQDQ---------LSHQRILAEENDKPAILYALLKLRLIRG 259
            |:.|         ::|| :||..|..|.         |....::.....:..:|:..|| :..:.
Human   373 DLAR---------ISLK-KEPLYVGVDDDKANATVDGLEQGYVVCPSEKRFLLLFTFLK-KNRKK 426

  Fly   260 KSIIFVNSIDRCYKVRL---FLEQFGIRACVLNSELPANIRIHTISQFNKGTYDIIIASDEHHME 321
            |.::|.:|   |..|:.   .|....:....::.:...|.|..|..||.......::.:|
Human   427 KLMVFFSS---CMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGTLLCTD----- 483

  Fly   322 KPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARG-NNKGSVLS 385
                                .|:||:|...|:.::.:|.|.|...||||.|||||| |.:|..|.
Human   484 --------------------VAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALL 528

  Fly   386 FVS---------MKESKVN----DSVEKKLCDSFAAQEGEQIIKNYQFKMEEVESFRYR-AQDCW 436
            .:.         :|:|||.    |....|:.| ..:|..:.|.|||         |.:: ||:.:
Human   529 ILRPEELGFLRYLKQSKVPLSEFDFSWSKISD-IQSQLEKLIEKNY---------FLHKSAQEAY 583

  Fly   437 RAATRVAVHDTRIREIKIEILNCEKLKAFFEENKRDL 473
            ::..|  .:|:            ..||..|..|..:|
Human   584 KSYIR--AYDS------------HSLKQIFNVNNLNL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	64/210 (30%)
		DEXDc	24..231	CDD:214692	66/213 (31%)
		HELICc	234..386	CDD:238034	36/155 (23%)
DDX18	NP_006764.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..169
		DEADc	179..386	CDD:238167	68/217 (31%)
		Q motif	179..207		6/20 (30%)
		DEXDc	194..382	CDD:214692	63/205 (31%)
		DEAD box	333..336		2/2 (100%)
		HELICc	400..529	CDD:238034	37/157 (24%)
		DUF4217	561..619	CDD:290667	15/69 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010