Protein Alignment Hlc and DBP9

DIOPT Version :9

• Sequence 1: NP_001285517.1
• Gene: Hlc / 33118
• FlyBaseID: FBgn0001565
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_013378.1
• Gene: DBP9 / 850982
• SGDID: S000004266
• Length: 594
• Species: Saccharomyces cerevisiae
• Alignment Length: 581
• Identity: 227/581 - (39%)
• Similarity: 330/581 - (56%)
• Gaps: 61/581 - (10%)

  Fly    11 FHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGK-DVVVRARTGSGKTATYALPLIQKILNS 74
            |....||.|:|:|:..:|:|.||||||.||||.|:.| |::.:|.||||||..|.:|:|:.||..
Yeast    19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEY 83

  Fly    75 KL---NASEQYVSAVVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVTQRHALSESP 136
            |.   |..|.....::|.||:||.:|...|:|:||..|.|.:|..:|:...:|:|... .|.:.|
Yeast    84 KKTIDNGEENGTLGIILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLST-LLMDQP 147

  Fly   137 DIVVATPANLLAYAEAG-SVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKHLP--PIYQAVLVS 198
            :|:|.||..||...:.. :.:.|..::.|||||.|||..:||:.|..::.::||  ...|..|:|
Yeast   148 EIIVGTPGKLLDLLQTKINSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMS 212

  Fly   199 ATLTDDVVRMKGLCLNNPVTLKLEEPEL-VPQDQLSHQRILAEENDKPAILYALLKLRLIRGKSI 262
            |||.||:..:|.....:|..||..:.|: ..|::|....:...|.||..:.|.:.||.||:||::
Yeast   213 ATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKLLQYYVKVSEFDKFLLCYVIFKLNLIKGKTL 277

  Fly   263 IFVNSIDRCYKVRLFLEQFGIRACVLNSELPANIRIHTISQFNKGTYDIIIASDE---------- 317
            ||||:|||.|:::|.:|||||::|:||||||.|.|.|.:.||||..|.::||:|:
Yeast   278 IFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDDTEYIKEEDDE 342

  Fly   318 ----HHMEKPGGKS----ATNRKSPR-------SGDMESSASRGIDFQCVNNVINFDFPRDVTSY 367
                |:.|....||    ..|.|.|.       ..|.|...|||:||:.|..|:|||.|....||
Yeast   343 IEEGHNTENQEEKSLEGEPENDKKPSKKKKVQVKKDKEYGVSRGVDFKNVACVLNFDLPTTAKSY 407

  Fly   368 IHRAGRTARGNNKGSVLSF-VSMKE-SKVNDSVEKKLCDSFAAQEGEQIIKN------------- 417
            :||.||||||...|:.:|| |.:|| .|...|:.:      .|::.|:|:..
Yeast   408 VHRVGRTARGGKTGTAISFVVPLKEFGKHKPSMLQ------TAKKDERILSRIIKQQSKLGLELQ 466

  Fly   418 -YQFKMEEVESFRYRAQDCWRAATRVAVHDTRIREIKIEILNCEKLKAFFEENKRDLQALRHDKP 481
             |:|..::||:||||.:|.:||.|:||:.:.|::|:|.|:|..||||..||||.::||:|||||.
Yeast   467 PYKFDQKQVEAFRYRMEDGFRAVTQVAIREARVKELKQELLASEKLKRHFEENPKELQSLRHDKE 531

  Fly   482 LRAIKVQSHLSDMPEYIVPKALKRVVGTSSSPVGASEAKQPRQSAAKAAFERQVN---DPL 539
            |...:||.||..:|:|::|:: .|..||....|....||: |.|..|....:..|   |||
Yeast   532 LHPARVQQHLKRVPDYLLPES-ARGNGTKVKFVPFHNAKK-RHSHKKGRVSKPKNGKVDPL 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	84/215 (39%)
		DEXDc	24..231	CDD:214692	82/214 (38%)
		HELICc	234..386	CDD:238034	73/176 (41%)
DBP9	NP_013378.1	SrmB	16..589	CDD:223587	224/578 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346484
Domainoid	1	1.000	128	1.000	Domainoid score	I1163
eggNOG	1	0.900	-	-		E2759_KOG0346
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6498
Inparanoid	1	1.050	366	1.000	Inparanoid score	I371
Isobase	1	0.950	-	0	Normalized mean entropy	S843
OMA	1	1.010	-	-		QHG53986
OrthoFinder	1	1.000	-	-		FOG0004019
OrthoInspector	1	1.000	-	-		oto100144
orthoMCL	1	0.900	-	-		OOG6_102730
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R293
SonicParanoid	1	1.000	-	-		X2772
TreeFam	1	0.960	-	-
	16	15.740