DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hlc and Ddx55

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_080685.2	Gene:	Ddx55 / 67848	MGIID:	1915098	Length:	600	Species:	Mus musculus

Alignment Length:	424	Identity:	109/424 - (25%)
Similarity:	189/424 - (44%)	Gaps:	72/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSQMTQKTVQFHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYAL 65
            |..:|:...:..::.|..|:|.|:.:||:...|.:||..|||.::.|||...|.||||||..:.:
Mouse     1 MEHVTEGAWESLQVPLHPRVLGALRELGFPHMTPVQSATIPLFMKNKDVAAEAVTGSGKTLAFVI 65

  Fly    66 PLIQKILNSKLNASEQYVSAVVLAPTKELCRQSRKVIEQLVESCGKVVRVADIADSSNDTVTQRH 130
            |:::.:|..:....:..|.|:|:.||:||..|..:|:....:...:..::..|...:.....:|.
Mouse    66 PILEILLRREEKLKKNQVGAIVITPTRELAIQIDEVLSHFTKHFPQFSQILWIGGRNPGEDVERF 130

  Fly   131 ALSESPDIVVATPANLL-AYAEAGSVVDL----KHVETLVVDEADLVFAYGYEKDFKRLIKHLPP 190
            . ....:|:||||..|. .:......:||    |.::.||:||||.:...|:|.....:::.||.
Mouse   131 K-QHGGNIIVATPGRLEDMFRRKAEGLDLASCVKSLDVLVLDEADRLLDMGFEASINTILEFLPK 194

  Fly   191 IYQAVLVSATLTDDVVRMKGLCLNNPVTLKLEEPELVPQ------DQLSHQRILAEENDKPAILY 249
            ..:..|.|||.|.:|..:....|.|||.:.::|..:...      .:|.:..::.:.::|...|.
Mouse   195 QRRTGLFSATQTQEVENLVRAGLRNPVRISVKEKGVAASSTQKTPSRLENHYMICKADEKFNQLV 259

  Fly   250 ALLKLRLIRGKSIIFVNSIDRCYKVRLFLEQFGIRACV--LNSELPANIR------IH------- 299
            ..|:.|. :.|.::|                |...|||  ....|.|.::      ||
Mouse   260 HFLRSRQ-QEKHLVF----------------FSTCACVEYYGKALEALLKKVKILCIHGKMKYKR 307

  Fly   300 --TISQFNKGTYDIIIASDEHHMEKPGGKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPR 362
              ...:|.|....|::.:|                         ..:||||...||.|:.:|.|.
Mouse   308 NKIFMEFRKLQSGILVCTD-------------------------VMARGIDIPEVNWVLQYDPPS 347

  Fly   363 DVTSYIHRAGRTARGNNKGSVLSF-VSMKESKVN 395
            :.::::||.|||||..:.||.|.| :.|:|:.:|
Mouse   348 NASAFVHRCGRTARIGHGGSALVFLLPMEEAYIN 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	64/213 (30%)
		DEXDc	24..231	CDD:214692	61/217 (28%)
		HELICc	234..386	CDD:238034	37/168 (22%)
Ddx55	NP_080685.2	DEADc	9..224	CDD:238167	64/215 (30%)
		Q motif	9..37		7/27 (26%)
		DEXDc	24..228	CDD:214692	60/204 (29%)
		DEAD box	171..174		2/2 (100%)
		Helicase_C	252..363	CDD:278689	34/152 (22%)
		DUF4217	403..462	CDD:290667
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010