DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hlc and ddx1

DIOPT Version :9

Sequence 1:	NP_001285517.1	Gene:	Hlc / 33118	FlyBaseID:	FBgn0001565	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001011133.1	Gene:	ddx1 / 496549	XenbaseID:	XB-GENE-969096	Length:	740	Species:	Xenopus tropicalis

Alignment Length:	708	Identity:	131/708 - (18%)
Similarity:	216/708 - (30%)	Gaps:	333/708 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQ------ 69
            |.|:.:...|.:||.::.|..||.||:.:|||:|.|.||::.|.||||||..:::|:||
Frog     4 FSEMGVMAEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETL 68

  Fly    70 -----------------KILNS-KLNASEQYVSAVVLAPTKELCRQSRKVIE------------- 103
                             .:||. ::|..::..|..:  .:..||.|||::.|
Frog    69 KDQQEGKKGKTSVKTGSTVLNKWQMNPYDRGSSFAI--GSDGLCCQSREIKEWHGCRSTRGVNKG 131

  Fly   104 ----------------------------------------------------------------- 103

Frog   132 KYYYEVSCHDQGLCRVGWSTLQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYI 196

  Fly   104 -----------------------------QLVESC------------------------------ 109
                                         .:..||
Frog   197 DIDNGTVKYSKNGKDLGLAFQIPAHLKNQAVFASCVLKNAELKFNFGEEDFKFPPKDGFVALSKA 261

  Fly   110 --GKVVR--------------------------VADIADSSNDTVTQRHALSESP---------- 136
              |.||:                          ..::|:.:.:.|.|.....:||
Frog   262 PDGHVVKSQNTGSAQVSQAKNLPNAPKALIIEPSRELAEQTLNNVKQFKKYVDSPKLRELLIIGG 326

  Fly   137 --------------DIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEKDFKRLIKH 187
                          ||||.||..:......|. ::|..|..||:||||.:.:.||.....|:...
Frog   327 VAAKEQLTLLENGVDIVVGTPGRIDDLISTGK-LNLSQVRFLVLDEADGLLSQGYSDFINRIHGQ 390

  Fly   188 LPPI------YQAVLVSATL-TDDVVRMKGLCLNNPVTLKLEEPELVPQ---------------- 229
            :|.:      .|.::.|||| :.||.::....::.|..:.|:..:.||:
Frog   391 IPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPETVHHVVVPVNPKKDKQ 455

  Fly   230 -DQLSHQRILAE-----ENDKPA------------ILYALLKLRLIR----GKSIIFVNSIDRCY 272
             ::|....|..:     :|.:|.            :|.....:|.|:    .::|||..:...|.
Frog   456 WERLGKNHIRTDGVHDKDNTRPGGNSAEMWSEAIKVLKGEYTVRAIKEHKMDQAIIFCRTKLDCD 520

  Fly   273 KV-RLFLEQFG-------IRACV-LNSELPANIRIHTISQFNKGTYDIIIASDEHHMEKPGGKSA 328
            .: :.|::|.|       ..:|| |:|:.....|.|.:.:|.|.....:|.:|
Frog   521 NMEQYFIQQGGGPDKKGHQFSCVCLHSDRKPQERKHNLERFKKCEVRFLICTD------------ 573

  Fly   329 TNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARGNNKGSVLSFVSMKESK 393
                         .|:||||...|..|||...|.:..:|:||.||..|....|..:|.|:.::.|
Frog   574 -------------VAARGIDIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVAAEKEK 625

  Fly   394 VNDSVEKKLCDSFAAQEGEQIIKNYQFKMEEVESFRYRAQDCWRAATRVAVHDTRIRE 451
            |...|    |.|                         |.:.|         |:||::|
Frog   626 VWYHV----CSS-------------------------RGKGC---------HNTRLKE 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	74/428 (17%)
		DEXDc	24..231	CDD:214692	73/443 (16%)
		HELICc	234..386	CDD:238034	40/181 (22%)
ddx1	NP_001011133.1	Interaction with dsRNA. /evidence=ECO:0000250\|UniProtKB:Q91VR5	1..448		77/446 (17%)
		DEAD-like_helicase_N	4..>64	CDD:391939	27/59 (46%)
		SPRY_DDX1	93..246	CDD:293933	10/154 (6%)
		DEADc_DDX1	264..430	CDD:350696	35/166 (21%)
		SrmB	284..>624	CDD:223587	78/365 (21%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010