Protein Alignment Hlc and Ddx1

DIOPT Version :9

• Sequence 1: NP_001285517.1
• Gene: Hlc / 33118
• FlyBaseID: FBgn0001565
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_524212.2
• Gene: Ddx1 / 40457
• FlyBaseID: FBgn0015075
• Length: 727
• Species: Drosophila melanogaster
• Alignment Length: 655
• Identity: 124/655 - (18%)
• Similarity: 190/655 - (29%)
• Gaps: 310/655 - (47%)

  Fly    11 FHELELDQRILKAVAQLGWQQPTLIQSTAIPLLLEGKDVVVRARTGSGKTATYALPLIQ------ 69
            |.|..:...:..|..:|.|..||.:|:.||||:|.|.||::.|.||||||..:.||::|
  Fly     4 FEEFGVLPELGMATDELDWTLPTDVQAEAIPLILGGGDVLMAAETGSGKTGAFCLPILQIVWETL 68

  Fly    70 ----------------------------------------------------------------- 69
                                                                             
  Fly    69 RDLEEGKAGKGGAIGGAVTPWTMSFFDRGNALAVTPDGLRCQSREFKEWHGCRATTGVRGKGKFY 133

  Fly    70 -------------------------------------------------------KILNSKLNAS 79
                                                                   .::...|:..
  Fly   134 FEATVTDEGLCRVGWSTQQANLDLGTCRMGFGFGGTGKKSNNRQFDDYGEAFGKADVIGCLLDLK 198

  Fly    80 EQYVS------------------------------------------------------------ 84
            .|.||
  Fly   199 NQEVSFTKNGQNLGVAFRLPDNLAKETFYPAVVLKNAEMQFNFGKTDFKYAPGNGFVGACQAGPE 263

  Fly    85 -------------------------AVVLAPTKELCRQSRKVIEQL--------VESCGKV--VR 114
                                     |:::.|::||..|:...||:.        |.|...:  ||
  Fly   264 HSKANPITGPAAGAPSAKPAPNAPQAIIMEPSRELAEQTYNQIEKFKYHLSNPEVRSLLLIGGVR 328

  Fly   115 VADIADSSNDTVTQRHALSESPDIVVATPANLLAYAEAGSVVDLKHVETLVVDEADLVFAYGYEK 179
            :.:          |:..|.:...|||.||..|.....:|.|: |.|....|:||||.:...||.:
  Fly   329 LEE----------QKAQLMQGTHIVVGTPGRLEEMINSGLVL-LTHCRFFVLDEADALLKQGYTE 382

  Fly   180 DFKRLIKHLPPI------YQAVLVSATL-TDDVVRMKGLCLNNP--VTLKLEE--PELV------ 227
            ...||.|.:|.|      .|.|:.|||| ..:|.:|....::.|  |.||.|:  ||.|
  Fly   383 LIDRLHKQIPKITSDGRRLQMVVCSATLHAFEVKKMAERLMHFPTWVDLKGEDAVPETVHHVVCL 447

  Fly   228 --PQDQLS-------------HQR--ILAEENDKPAILYALLKLRLIRG-------------KSI 262
              ||...:             |.|  :....:.|..:..|   ::|::|             ::|
  Fly   448 VDPQMDTTWQSLRQPIGTDGVHDRDNVHPGNHSKETLSQA---VKLLKGEYCVHAIDKHNMDRAI 509

  Fly   263 IFVNSIDRCYKVRLFLEQFGIR--ACV-LNSELPANIRIHTISQFNKGTYDIIIASDEHHMEKPG 324
            ||..:...|..:..||.|.|.:  :|| |:.:.....|...:..|.:.....:|.:|
  Fly   510 IFCRTKQDCDNLERFLRQRGGKHYSCVCLHGDRKPQERKENLEMFKRQQVKFLICTD-------- 566

  Fly   325 GKSATNRKSPRSGDMESSASRGIDFQCVNNVINFDFPRDVTSYIHRAGRTARGNNKGSVLSFVSM 389
                             .|:||:|...:..:||...|.|.|:|:||.||..|....|..:|.|:.
  Fly   567 -----------------VAARGLDITGLPFMINVTLPDDKTNYVHRIGRVGRAERMGLAISLVAT 614

  Fly   390 KESKV 394
            ...||
  Fly   615 VPEKV 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hlc	NP_001285517.1	P-loop_NTPase	11..220	CDD:304359	75/438 (17%)
		DEXDc	24..231	CDD:214692	80/446 (18%)
		HELICc	234..386	CDD:238034	37/169 (22%)
Ddx1	NP_524212.2	P-loop_NTPase	4..>62	CDD:304359	25/57 (44%)
		SPRY_DDX1	91..242	CDD:293933	4/150 (3%)
		SrmB	279..>612	CDD:223587	91/371 (25%)
		P-loop_NTPase	<280..426	CDD:304359	43/156 (28%)
		Helicase_C	492..602	CDD:278689	30/134 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040